Association between eosinophilia and lymphocytosis with functional outcomes of patients with Hirschsprung disease following transabdominal YanceySoave pull-through

Introduction: Hirschsprung disease (HSCR) is a disorder caused by the failure of neural crest migration leading to an aganglionic colon and functional obstruction. Transabdominal YanceySoave pull-through is one of the definitive therapies for this condition. Prognostic factors, including sex, aganglionosis type, age at definitive surgery, nutritional status, eosinophilia and lymphocytosis, might influence the outcomes of the pull-through. We evaluated the functional outcomes of HSCR patients after Yancey-Soave surgery and associated them with the prognostic factors. Materials and Methods: The study included Hirschsprung patients aged �3 and <18 years who underwent Yancey-Soave surgery at our hospital. The functional outcomes were evaluated using the Krickenbeck classification to determine voluntary bowel movement (VBM), constipation and soiling. Results: Most (82.6) patients showed VBM, 26.1 had constipation and 4.3 suffered from soiling. Among 23 patients who received Yancey�Soave surgery, 8 (34.8) had eosinophilia and 5 (21.7) had lymphocytosis. However, no significant differences were observed between eosinophilia and non-eosinophilia groups for VBM (p=1.0), constipation (p= 0.621) or soiling (p=0.738). Similarly, no significant differences were found between lymphocytosis and non-lymphocytosis groups for VBM (p=1.0), constipation (p=0.545) or soiling (p=0.973). Moreover, no other prognostic factors affected the functional outcomes after Yancey� Soave surgery (p>0.05). Conclusion: Our study shows that eosinophilia and lymphocytosis might not affect the functional outcome of patients with HSCR following Yancey-Soave surgery. In addition, sex, aganglionosis type, age at definitive surgery and nutritional status might not influence the functional outcome after definitive surgery. Further, a more extensive study is essential to clarify our findings. © 2024 Elsevier B.V., All rights reserved.