Effect of snakehead fish (Channa striata) extracts on liver function in rats which receiving anti-tuberculosis

Tuberculosis is one of communicable disease which have attention of goverment with various programme involving communities in order to eradicating numbers of patients and improve quality of life of patients. Hepatotoxicity due to anti-tuberculosis drugs is a serious problem in the world especially for TB patients. Data reported that drug induce liver injury cases reached 33. Meanwhile, snakehead fish extract reported have hepatoprotector activity. The aims of the research were to determine effect of snakehead fish extract on liver function in rats which receiving anti-tuberculosis in 21^st days. Twenty rats were divided into 4 groups that are normal control groups (received CMC Na solution), negative control groups (received snakehead fish extract), treatment I (received anti-tuberculosis drugs in FDC regimen), treatment II (received anti-tuberculosis drugs and snakehead fish extract). SGPT, SGOT, ALP, and albumin were measured at baseline, 7^th, 14^th, and 21^st days by spectrophotometer. The results showed that treatment I had hepatotoxic condition based on increases of SGPT and SGOT values compared to baseline and normal control groups. In general, there were increasing of SGPT and SGOT compared to baseline data for all groups. Rats groups received Anti-tuberculosis FDC has significant difference with normal control groups at 21^st days. Meanwhile, ALP value of negative control and treatment II have increased from baseline to 21^st days. In addition, albumin of negative control and treatment II have increased from baseline until 21^st days. Whereas, normal control and treatment I were decreased. Increased level of albumin of previous groups due to albumin component in snakehead fish extract. Based on previous data, it could be concluded that orally administration of anti-tuberculosis for 21^st days showed occurrence of hepatotoxic on rats and supplementation of snakehead fish extract could repaired the parameters become normal. © 2020 Elsevier B.V., All rights reserved.