Synergistic Effect of Low Neutrophil Lymphocyte Ratio With Physical Activity on Quality of Life in Type 2 Diabetes Mellitus: A Community-Based Study

Background: Physical inactivity and Type 2 diabetes mellitus (T2DM)�associated inflammatory biomarkers are correlated with poor quality of life (QoL). However, no study has investigated the synergistic effect of physical activity (PA) and lower neutrophil�lymphocyte ratio (NLR) on QoL. Objective: We examined the independent and synergistic effects of PA and inflammatory biomarkers on three domains of QoL in T2DM. Methods: This cross-sectional study included 294 patients with T2DM from community clinics in Indonesia. The 36-item Short Form Survey and a questionnaire about PA engagement were used to measure QoL and metabolic equivalent of task (MET)-hr/week, respectively. Inflammatory biomarkers were measured in fasting blood. Adjusted coefficients β and 95 confidence interval (CI) were estimated using multiple linear regression. The synergistic effect was analyzed using additive interaction for linear regression. Results: Patients with PA � 7.5 MET-hr/week exhibited significantly higher total QoL (β = 8.41, 95 CI = 6.04, 10.78) and physical component score (PCS; β = 13.90, 95% CI = 10.52, 17.29) than those with PA < 7.5 MET-hr/week. Patients with NLR < 1.940 had significantly higher total QoL (β = 4.76, 95% CI = 3.41, 6.11), mental component score (MCS; β = 2.62, 95% CI = 0.75, 4.49), and PCS (β = 6.89, 95% CI = 4.97, 8.82) than patients with NLR � 1.940. PA � 7.5 MET-hr/week and NLR < 1.940 exhibited a synergistic effect on total QoL, MCS, and PCS. Conclusions: High PA level and low NLR had a positive synergistic effect on QoL among patients with T2DM. © 2020 Elsevier B.V., All rights reserved.