Engineering of Bioceramics-Based Scaffold and Its Clinical Applications in Dentistry

The fundamental technology is through the preparation of biomaterials as an artificial scaffold, to act as a synthetic extracellular matrix (ECM). Scaffold should be used in combination with cells and/or signaling molecules that have potential to accelerate tissue regeneration. Because of the similarity to the human bone, so far calcium phosphate ceramics are very popular materials for diverse clinical application in dentistry. Hydroxyapatite-based calcium phosphate compounds and bioactive glass are considered as high-potential scaffolds, especially for bone tissue engineering in dentistry, due to their osteoconductive properties. There are a lot of methods applied to achieve ideal scaffold in terms of ideal architectural structure, physical and mechanical properties, and biodegradability of the scaffold, including its proper biological properties. © 2019 by The American Ceramic Society. All rights reserved.