The effectiveness of platelet-rich plasma for chemotherapy extravasation wound management: A case report

Chemotherapy extravasation is a serious iatrogenic complication, especially with vesicant agents such as epirubicin. In severe cases, it can lead to extensive tissue necrosis and compartment syndrome. While surgical intervention is the mainstay treatment for acute complications, novel adjuncts like platelet-rich plasma (PRP) may support wound healing in the recovery phase. A 66-year-old woman with a history of non-Hodgkins lymphoma developed swelling, bullae, and pain in her right hand following intravenous epirubicin infusion. Compartment syndrome was suspected, and emergency fasciotomy with debridement was performed. Despite initial surgical and medical management, delayed wound healing and recurrent necrosis were observed. Autologous PRP mixed with mupirocin was applied topically twice daily. Accelerated granulation, epithelialization, and functional recovery of the hand were noted within days of PRP initiation. This case illustrates the regenerative potential of PRP in promoting wound healing following chemotherapeutic tissue injury. Its application in extravasation wounds remains rare in the literature, and this report adds to growing interest in PRP as a safe and potentially effective adjunctive therapy in complex oncologic wounds. © 2025 Journal of Cancer Research and Therapeutics.