Anredera cordifolia Extract in Reducing Immunoglobulin E Expression in Wistar Rats Allergic Model

Allergic rhinitis (AR) is a prevalent health issue worldwide, characterized by an inflammatory condition of the nose mediated by immunoglobulin E (IgE). Anredera cordifolia (AC), the binahong plant in Indonesia, has been extensively used in herbal medicine since ancient times. AC contains secondary metabolites, such as flavonoids, with anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Many flavonoid compounds with anti-inflammatory activity can potentially treat nasal inflammation, such as allergic rhinitis. Quercetin, a natural polyphenol flavonoid, has anti-allergic mechanism by inhibiting histamine synthesis, regulating Th1/Th2 balance, and reducing Ig E antibody production in B cells. This study aims to determine whether there is a decrease in IgE expression after administration of AC extract in the Wistar rats allergic model. The research was conducted on 36 Wistar rats classified into nine groups: control group without any intervention (K1), negative treatment group (K2), positive standard treatment group (K3), treatment group with hydrogel intranasal AC extract of 2.5 (P1), 5 (P2), and 7.5 (P3), and treatment group with oral AC extract of 25 mg/200 g BW (P4), 50 mg/200 g BW (P5), and 75 mg/200 g BW (P6). Afterward, Ig E expression analysis was performed using ELISA. The t-test results for treatment groups applied with hydrogel intranasal AC extract of 2.5 revealed a significant difference in decreasing IgE levels before and after treatment. In conclusion, the finding supports that AC extract exerts its anti-allergy properties by suppressing IgE levels in the Wistar rats allergic model. Copyright © 2025 by Indonesian Journal of Pharmacy (IJP).