Quantitative evaluation of the biomechanical and viscoelastic properties of the dog patellar tendon in response to neuromuscular blockade at different stifle angles

Anggoro, Dito and Purba, Melpa Susanti and Nishida, Norihiro and Itoh, Harumichi and Itamoto, Kazuhito and Nemoto, Yuki and Nakaichi, Munekazu and Sunahara, Hiroshi and Tani, Kenji (2024) Quantitative evaluation of the biomechanical and viscoelastic properties of the dog patellar tendon in response to neuromuscular blockade at different stifle angles. PLoS ONE, 19 (1 Janu): e0292453. ISSN 19326203

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Abstract

The patellar tendon (PT) is crucial for maintaining stability and facilitating movement in the stifle joint. Elastography has been recognized as a prominent method for evaluating PT properties in humans and dogs. The utilization of oscillation methods in canine studies remains limited despite their extensive documentation in human studies. Our study represents the first effort to quantitatively assess and compare the effects of muscle relaxant on the biomechanical and viscoelastic characteristics of the PT at varying stifle angles in living dogs. Five healthy female beagles were used in this study. Biomechanical (tone, stiffness, and decrement) and viscoelastic (relaxation time and creep) properties of the PT were measured using MyotonPRO (Myoton Ltd, Estonia) prior to and following administration of rocuronium (0.5 mg/kg/body weight) at normal, extended, and flexed positions. Rocuronium was selected for its safety, controllability, and widespread clinical use in veterinary anesthesia. Two-way analysis of variance showed that tone, stiffness, and decrement were significantly higher (P < 0.001) in the control group than in the muscle relaxation group. At the same time, relaxation time and creep were significantly lower (P < 0.001) in the control group than in the muscle relaxation group. The findings indicate that stifle angle position and muscle rexalant administration fundamentally alter the biomechanical loading conditions of the PT, leading to changes in its viscoelastic properties. Therefore, this novel quantitative data could benefit clinical settings that necessitate accurate and objective methods for risk identification and monitoring PT biomechanics in dogs. © 2024 Anggoro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access
Uncontrolled Keywords: Animals; Biomechanical Phenomena; Dogs; Female; Humans; Knee Joint; Neuromuscular Blockade; Patellar Ligament; Rocuronium; Stifle; mylan; propofol; rocuronium; rocuronium; animal experiment; animal model; Article; biomechanics; capnometry; controlled study; dog; elastography; electrocardiography; female; knee stiffness; muscle relaxation; neuromuscular blocking; nonhuman; patellar reflex; pulse oximetry; quantitative analysis; rebreathing; relaxation time; rigidity; viscoelasticity; animal; biomechanics; dog; human; knee; patellar ligament; physiology; stifle
Subjects: S Agriculture > SF Animal culture
Divisions: Faculty of Veterinary Medicine
Depositing User: Yulistiarini Kumaraningrum KUMARANINGRUM
Date Deposited: 04 Nov 2024 06:27
Last Modified: 04 Nov 2024 06:27
URI: https://ir.lib.ugm.ac.id/id/eprint/10696

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