Sea Cucumber-Based Hydroxyapatite-Chitosan Ameliorate Serum Liver Enzymes and Cytokine Levels in Albino Rats with Femoral Bone Defect

Fikri, Faisal and Purnomo, Agus and Chhetri, Shekhar and Purnama, Muhammad Thohawi Elziyad (2023) Sea Cucumber-Based Hydroxyapatite-Chitosan Ameliorate Serum Liver Enzymes and Cytokine Levels in Albino Rats with Femoral Bone Defect. Indian Veterinary Journal, 100 (7). 23 – 26. ISSN 00196479

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Abstract

This study aimed to evaluate sea cucumber-based hydroxyapatite-chitosan (HA-Ch) as a bone graft in cases of bone defects on the variables of serum liver enzymes, IL-4, IL-6, calcium and phosphate levels. A total of 18 albino rats were used in the study, grouped into (C) control group, (T1) polyethylene glycol (PEG) group, and (T2) HA-Ch group. The treatment was carried out for 42 days, respectively. Surgical procedures and modeling of bone defects were carried out using standard methods. Data analyzed statistically using one-way ANOVA followed by post hoc Tukey multiple comparisons test (p<0.05). In result, ALP, IL-4, IL-6, calcium and phosphate levels reported significantly improved at T2 group compared to T1 and C groups. Meanwhile, ALT, AST, and GGT levels were not significant in all groups. In conclusion, HA-Ch gel can act as a bone graft to repair bone defects during the ossification process. © 2023 Indian Veterinary Assocaition. All rights reserved.

Item Type: Article
Additional Information: Cited by: 7
Uncontrolled Keywords: bone defect, domesticated animals, hydroxyapatite, sea cucumber
Subjects: Veterinary Medicine
Divisions: Faculty of Veterinary Medicine
Depositing User: Sri JUNANDI
Date Deposited: 06 Nov 2024 01:08
Last Modified: 06 Nov 2024 01:08
URI: https://ir.lib.ugm.ac.id/id/eprint/10840

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