Fikri, Faisal and Purnomo, Agus and Chhetri, Shekhar and Purnama, Muhammad Thohawi Elziyad (2023) Sea Cucumber-Based Hydroxyapatite-Chitosan Ameliorate Serum Liver Enzymes and Cytokine Levels in Albino Rats with Femoral Bone Defect. Indian Veterinary Journal, 100 (7). 23 – 26. ISSN 00196479
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This study aimed to evaluate sea cucumber-based hydroxyapatite-chitosan (HA-Ch) as a bone graft in cases of bone defects on the variables of serum liver enzymes, IL-4, IL-6, calcium and phosphate levels. A total of 18 albino rats were used in the study, grouped into (C) control group, (T1) polyethylene glycol (PEG) group, and (T2) HA-Ch group. The treatment was carried out for 42 days, respectively. Surgical procedures and modeling of bone defects were carried out using standard methods. Data analyzed statistically using one-way ANOVA followed by post hoc Tukey multiple comparisons test (p<0.05). In result, ALP, IL-4, IL-6, calcium and phosphate levels reported significantly improved at T2 group compared to T1 and C groups. Meanwhile, ALT, AST, and GGT levels were not significant in all groups. In conclusion, HA-Ch gel can act as a bone graft to repair bone defects during the ossification process. © 2023 Indian Veterinary Assocaition. All rights reserved.
Item Type: | Article |
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Additional Information: | Cited by: 7 |
Uncontrolled Keywords: | bone defect, domesticated animals, hydroxyapatite, sea cucumber |
Subjects: | Veterinary Medicine |
Divisions: | Faculty of Veterinary Medicine |
Depositing User: | Sri JUNANDI |
Date Deposited: | 06 Nov 2024 01:08 |
Last Modified: | 06 Nov 2024 01:08 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/10840 |