Doxycycline Incorporation Into Gelatin- Carbonate Apatite Membrane as Adjuvant Post Gingival Curettage

Introduction: Tissue destruction in periodontitis caused by chronic inflammation and form of host tissue response. Local drug delivery, such as doxycycline has antibacterial and host modulation properties. Drug vehicle like gelatine and carbonate apatite has good biocompatibility and enhance regeneration process periodontal defect. Objective: This study aimed to examine effect of doxycycline incorporated into gelatine-carbonate apatite membrane as adjuvant for periodontitis after gingival curettages. Methods: Gingival curettages were performed to forty-five periodontal pocket points from eight patients, then adjuvant material was applied to each pocket according to the treatment group: gelatine– carbonate apatite membrane, gelatine–carbonate apatite–doxycycline membrane, or doxycycline solution. Treatment was chosen by simple randomization. Periodontal pack was placed for seven days. Clinical evaluation was carried out 7-, 21-, and 28-days post-operative for Papillary Bleeding Index (PBI) and 21-,28-days for Pocket Depth (PD) and Relative Attachment Level (RAL). The data were statistically analysed using the Kruskal Wallis test, followed by the U Mann Whitney test. Results: PBI scores were reduced since the 7th day then remained 0 until the last day of examination in all groups. All groups showed reduction of PD and Ral from day 0 to day 28. Greatest reduction of PD and RAL were examined on the gelatine– carbonate apatite group (p<0.05). Pocket with gelatine–carbonate apatite–doxycycline membrane and doxycycline solution as adjuvant materials showed no significant difference. Conclusion: Doxycycline incorporated into gelatine-carbonate apatite membrane was not as effective as gelatine-carbonate apatite membrane to treat shallow pockets. © 2023 UPM Press. All rights reserved.