Donor Compatibility on Crossmatch-test Result of Freeze-dried Homologous Platelet-rich Plasma

Introduction: Homologous platelet-rich plasma (hPRP) is made from unused products from healthy blood donors and used for periodontal tissue regeneration therapy. This study tried to explore the benefits of this unused product to enhance community dental health services. The Fresh hPRP (liquid form) is obtained from the blood by centrifuge or sedimentation. The red blood cells could be separated from the plasma to sedimentation for a few hours and let the cells settle by gravity. Another type is Freeze-dried hPRP (FD-hPRP) (powder form) has been proposed as a consistent result for product standardization and fabrication of a ready-to-use product for feature uses. The hPRP must be passed from the crossmatch test to prevent an immune reaction. This research aimed to determine the difference of donor compatibility on the crossmatch result between single centrifugation and sedimentation methods. Methods: Twenty samples of blood type O were divided into four groups; group I was fresh hPRP centrifugation, group II was fresh hPRP sedimentation, group III was FD-hPRP centrifugation, and group IV was FD-hPRP sedimentation. The crossmatch test was done to determine donor compatibility utilizing the gel-test method. Results: The data were interpreted using the chi-square test, and it showed that all four groups in the crossmatch test were 100 compatible. Conclusion: The conclusion indicated that FD-hPRP groups event obtained by both methods and fresh hPRP were efficiency is guaranteed, as sedimentation and freeze-dried products decrease the need for specialized facilities and staff even are readily obtainable on request. © 2023 UPM Press. All rights reserved.