A microfluidic organ-on-a-chip: into the next decade of bone tissue engineering applied in dentistry

Syahruddin, Muhammad Hidayat and Anggraeni, Rahmi and Ana, Ika Dewi (2023) A microfluidic organ-on-a-chip: into the next decade of bone tissue engineering applied in dentistry. Future Science OA, 9 (10). ISSN 20565623

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Abstract

A comprehensive understanding of the complex physiological and pathological processes associated with alveolar bones, their responses to different therapeutics strategies, and cell interactions with biomaterial becomes necessary in precisely treating patients with severe progressive periodontitis, as a bone-related issue in dentistry. However, existing monolayer cell culture or pre-clinical models have been unable to mimic the complex physiological, pathological and regeneration processes in the bone microenvironment in response to different therapeutic strategies. In this point, ‘organ-on-a-chip' (OOAC) technology, specifically ‘alveolar-bone-on-a-chip', is expected to resolve the problems by better imitating infection site microenvironment and microphysiology within the oral tissues. The OOAC technology is assessed in this study toward better approaches in disease modeling and better therapeutics strategy for bone tissue engineering applied in dentistry. Plain language summary Bone-related issues have been widely focused on in the field of dentistry due to oral cancers, trauma, injuries and the high incidence of periodontitis (a serious gum infection which causes bone damage and tooth loss). To overcome this condition, several strategies have been developed involving tissue engineering approaches and drug discovery. To provide better drugs for periodontitis, it is important to study the ways in which tissues and cells work together as well as the disease mechanisms, and cell interactions with drugs, other therapeutics agents, or biomaterials. For this, cell studies are needed, but the current research cannot replicate the disease environment and therefore cannot show exactly what happens in real sick areas. In this review, a new idea is explored called organ-on-a-chip technology, where scientists make small models that work like our organs, which could help them find better ways to treat dental and bone problems. © 2023 The Authors.

Item Type: Article
Additional Information: Cited by: 3; All Open Access, Gold Open Access
Uncontrolled Keywords: aflatoxin B1; angiopoietin 1; biomaterial; bisphosphonic acid derivative; calcium phosphate; calcium silicate; cisplatin; corticosteroid; dental material; dimeticone; glycoprotein; hydrogel; macrogol; osteocalcin; pitavastatin; plexin; poly(methyl methacrylate); polycarbonate; polyhydroxyalkanoic acid; polyimide; polystyrene; polyvinylchloride; silicone; acute toxicity; Aggregatibacter actinomycetemcomitans; alveolar bone; angiogenesis; antibacterial activity; biocompatibility; biofilm; blood brain barrier; bone development; bone regeneration; bone remodeling; bone tissue; cell culture; cell differentiation; cell interaction; cell proliferation; cell survival; cell viability; chondrocyte; coculture; cytotoxicity; dentistry; dysbiosis; enzyme kinetics; femur head necrosis; fluorescence imaging; fracture healing; freeze drying; gene expression; head and neck cancer; head and neck squamous cell carcinoma; human; hydrostatic pressure; immunohistochemistry; mechanical stimulation; microbial community; microfluidic analysis; nanofabrication; neural stem cell; neuromuscular junction; neurosurgery; nonhuman; odontoblast; osteocyte; osteoporosis; osteosarcoma; overall survival; particulate matter; periodontal disease; periodontal ligament; periodontitis; personalized medicine; Porphyromonas gingivalis; prevalence; quality of life; Review; risk assessment; soft tissue inflammation; Streptococcus gordonii; Streptococcus oralis; Streptococcus salivarius; systemic disease; temporomandibular joint; tissue engineering; tissue regeneration; tooth development; tooth disease; tooth eruption; tooth germ; toxicity testing; tumor cell culture; tumor microenvironment; umbilical vein endothelial cell; Wnt signaling; wound healing
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Doctoral Program in Dental Science
Depositing User: Sri JUNANDI
Date Deposited: 07 Nov 2024 03:35
Last Modified: 07 Nov 2024 03:35
URI: https://ir.lib.ugm.ac.id/id/eprint/10995

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