Fredianto, Meiky and Herman, Herry and Dias Ismiarto, Yoyos and Purba, Ambrosius and Putra, Agung and Hidayah, Nurul (2023) Combination Effect of Rotator Cuff Repair with Secretome-hypoxia MSCs Ameliorates TNMD, RUNX2, and Healing Histology Score in Rotator Cuff Tear Rats. Archives of Bone and Joint Surgery, 11 (10). 617 -624. ISSN 23454644
Combination Effect of Rotator Cuff Repair with Secretome-hypoxia MSCs Ameliorates TNMD, RUNX2, and Healing Histology Score in Rotator Cuff Tear Rats.pdf - Published Version
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Abstract
Objectives: In order to treat a rat model of rotator cuff rupture, this work concentrated on the expression of TNMD and RUNX2, followed by rotator cuff repair and secretome-hMSCs. Methods: A total of thirty 10-weeks-old male Sprague–Dawley rats were separated into five groups randomly, RC on week 0, lesion treated with a rotator cuff repair and saline (RC + NaCl group, n = 6) for 2 and 8 weeks, and lesion treated with a rotator cuff repair and secretome-hMSCs (RC + secretome-hMSC group, n = 6) for 2 and 8 weeks. The supraspinatus and infraspinatus muscle–tendon units were obtained for histological and biomechanical investigation at 0, 2 and 8 weeks following injury. Results: The findings showed that, in comparison with the RC + NaCl group, secretome-hMSCs significantly improved tendon repair by upregulating TNMD and RUNX2 expression and histology score. Conclusion: Combining Secretome-hypoxia MSCs with RC healing may help rats with rotator cuff tears. © 2023 Mashhad University of Medical Sciences. All rights reserved.
Item Type: | Article |
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Additional Information: | Cited by: 0 |
Uncontrolled Keywords: | sodium chloride; transcription factor RUNX2; adult; animal cell; animal experiment; animal model; animal tissue; Article; biomechanics; cell hypoxia; controlled study; histology; infraspinatus muscle; male; mesenchymal stem cell; nonhuman; protein expression; rat; rat model; rotator cuff repair; rotator cuff rupture; secretome |
Subjects: | R Medicine > RZ Other systems of medicine |
Divisions: | Faculty of Medicine, Public Health and Nursing > Nursing |
Depositing User: | Ani PURWANDARI |
Date Deposited: | 27 May 2024 08:38 |
Last Modified: | 27 May 2024 08:38 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/1153 |