ASSOCIATION OF PRE-OPERATIVE SERUM LEVEL OF INTERFERON GAMMA WITH CLINICAL PARAMETERS OF OVARIAN CANCER PATIENTS

Introduction/Background Several clinical variables are proven as prognosis determinants in ovarian cancer, including age, BMI, grade, histopathological subtype, stage, and debulking surgery. The level of interferon-gamma (IFN-γ) as a pro-tumor agent, is also considered in determining the prognosis of ovarian cancer. However, the study regarding the association between the level of IFN-γ in serum and clinical parameters among ovarian cancer patients is limited. We investigate the association between pre-operative IFN-γ levels in serum and various clinical parameters among ovarian cancer patients

Methodology We collected serum from 15 patients with ovarian carcinoma who underwent primary surgery. The level of IFN-γ in serum was quantified using ELISA and its association with various clinical parameters was analyzed
Results Higher average of IFN-γ level in serum found in patients with normal BMI (mean=0.82 pg/ml, p=0,951), age >60 years (mean=0.62 pg/ml, p=0,191), high-grade (mean=0.84 pg/ml, p=0,861), non-serous subtypes (mean=1.48, p=0,067), advanced stage (mean=0.87 pg/ml, p=0,611), and suboptimal surgery (mean=1.11 pg/ml, p=0,132) in comparison with overweight, age<60, low grade, serous, early stage and optimal surgery (0.78, 0.62, 0.74, 0.36, 0.55, 0.36 pg/ml), but there were no statistically significant differences.
Conclusion There are no significant association between IFN-γ levels in serum and some clinical parameters including age, BMI, grade, histopathological subtype, stage, and residual disease of ovarian carcinoma patients.