Gunadi, Gunadi and Puspitarani, Dyah Ayu and Vujira, Khanza Adzkia and Utami, Fadila Dyah Trie and Devana, Edita Mayda and Halim, Fiqih Vidiantoro and Iskandar, Kristy and Makhmudi, Akhmad (2023) Collagen gene cluster expression and liver fibrogenesis in patients with biliary atresia: a preliminary study. BMC RESEARCH NOTES, 16 (1): 356. ISSN 17560500
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Abstract
ObjectiveBiliary atresia (BA) is a progressive fibro-obliterative disease of the biliary tract, which results in end-stage liver disease. However, liver fibrosis progression may continue even after Kasai surgery. Recent evidence showed that collagen plays a pivotal role in the progression of liver fibrosis in BA. However, most studies were conducted in developed countries. We investigated the expressions of the collagen gene cluster (COL6A1, COL6A2, COL6A3, and COL1A1) in BA patients in Indonesia.ResultsThere was a significant down-regulated expression of COL6A1 (Delta CT 9.06 +/- 2.64 vs. 5.42 +/- 2.41; p = 0.0009), COL6A2 (Delta CT 8.25 +/- 2.07 vs. 5.77 +/- 3.51; p = 0.02), COL6A3 (Delta CT 11.2 +/- 6.08 vs. 6.78 +/- 3.51; p = 0.024), and COL1A1 (Delta CT 3.26 +/- 1.71 vs. 0.19 +/- 2.76; p = 0.0015) in BA patients compared to controls. Interestingly, the collagen gene cluster expressions were significantly associated with the presence of cirrhosis (p = 0.0085, 0.04, and 0.0283 for COL6A1, COL6A2, and COL6A3, respectively). In conclusion, our study shows the changes in the collagen gene cluster, particularly collagen type I and VI, expressions in patients with BA in a particular developing country. Our findings suggest the role of these collagen gene clusters in the liver fibrogenesis of BA.
Item Type: | Article |
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Uncontrolled Keywords: | Biliary atresia; Collagen gene cluster expressions; Developing country; Kasai procedure; Liver fibrogenesis |
Subjects: | R Medicine > RD Surgical Divisions |
Divisions: | Faculty of Medicine, Public Health and Nursing > Surgical Divisions |
Depositing User: | Sri JUNANDI |
Date Deposited: | 13 Dec 2024 05:54 |
Last Modified: | 13 Dec 2024 05:54 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/11822 |