CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients: A Cross-sectional Study

Cahyanur, Rahmat and Irawan, Cosphiadi and Lisnawati, Lisnawati and Adham, Marlinda and Kamal, Achmad Fauzi and Utomo, Ahmad Rusdan Handoyo and Hardianti, Mardiah Suci and Mansyur, Muchtaruddin and Salamah, Thariqah (2023) CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients: A Cross-sectional Study. Acta Medica Indonesiana, 55 (3). 261 -268. ISSN 01259326

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Abstract

Background: There are correlations between tumor staging, lymph node involvement, and patient survival in Nasopharyngeal cancer (NPC) which is one of the most common types of cancer in Indonesia. The inflammation process plays a role in tumor progression over the long term and this marked by increased proinflammatory cytokine and gene overexpression. This study aims to identify differentially expressed genes (DEGs) in NPC using T and N staging. Methods: This is a cross-sectional study of NPC patients in Cipto Mangunkusumo, Jakarta, between 2018 and 2022. DEGs were identified based on the amount of mRNA detected on paraffin blocks with a 1.5-to-1.5-fold change and an adjusted p-value of <0.05. Results: We included 48 subjects. The mean age of subjects was 47.75 (10.48) years, and most were male (77.1). Non-keratinized squamous cell carcinoma was the most common histopathology type. Differences in the tumor size of the T4 and non-T4 in metastatic (33.3) group when compared to the non-metastatic (37.5) group were insignificant (p = 0.763). The proportion of N3 subjects in the metastatic vs non-metastatic group was different significantly (83.3 vs. 50, p = 0.030). Gene expression analysis showed that C-X-C motif ligand 8 (CXCL8), matrix metalloproteinase-1 (MMP1), matrix metalloproteinase-1 (MMP2), and fibronectin-1 (FN1) genes of the T4 and non-T4 group to be different significantly. Conclusion: There was significant finding in the N3 subjects of the metastatic and non-metastatic groups. The DEGs of CXCL8, MMP1, MMP2, and FN1 were statistically significant in the T4 when compared to the non-T4 group. © 2023, Indonesian Society of Internal Medicine. All rights reserved.

Item Type: Article
Additional Information: Cited by: 1
Uncontrolled Keywords: Cross-Sectional Studies; Female; Gene Expression; Humans; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; gelatinase A; interstitial collagenase; MMP1 protein, human; MMP2 protein, human; cross-sectional study; female; gene expression; genetics; human; male; metabolism; middle aged; nasopharynx carcinoma; nasopharynx tumor
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Public Health and Nursing > Nursing
Depositing User: Mukhotib Mukhotib
Date Deposited: 17 May 2024 04:16
Last Modified: 17 May 2024 04:16
URI: https://ir.lib.ugm.ac.id/id/eprint/1259

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