Endometrial receptivity defects MUC-1 and COX-2 polymorphisms in endometriosis

Budihastuti, Uki Retno and Dasuki, Djaswadi and Sadewa, Ahmad Hamim and Utoro, Totok (2023) Endometrial receptivity defects MUC-1 and COX-2 polymorphisms in endometriosis. Journal of Medicine and Life, 16 (10). pp. 1503-1507. ISSN 1844122X

[thumbnail of 352.pdf] Text
352.pdf - Published Version
Restricted to Registered users only
Available under License Creative Commons Attribution.

Download (224kB)

Abstract

The endometrium produces MUCIN-1 (MUC-1) and cyclooxygenase-2 (COX-2), which are essential for implantation. MUC-1 is required for adhesion, while COX-2 is necessary for decidualization. Variations or polymorphisms in MUC-1 and COX-2 can lead to changes in endometrial receptivity. This study investigated the relationship between MUC-1 and COX-2 polymorphisms and endometrial receptivity in endometriosis patients. Blood DNA samples were collected from 35 patients with endometriosis and 32 healthy patients between days 19 to 24 of their menstrual cycle (secretory phase). MUC-1 polymorphism was determined using the Amplification Refractory Mutation Sys-tem (ARMS), and COX-2 gene polymorphism was assessed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The frequency distribution of gene polymorphisms between the two groups was compared using bivariate analysis. There were seven genotypic combinations of MUC-1 and COX-2: AAGC; AAGG; GACC; GAGC; GAGG; GGGC; GGGG. The AAGC genotype combination test was significant, with an OR=6.43 (95 CI:1.09–7.62) and p=0.01. In conclusion, combining MUC-1 and COX-2 (AAGC) genotypes results in endometrial receptivity defects in endometriosis. © 2023, Carol Davila University Press. All rights reserved.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access
Uncontrolled Keywords: Cyclooxygenase 2; Endometriosis; Endometrium; Female; Humans; Mucin-1; Polymorphism, Genetic; cyclooxygenase 2; mucin 1; endometriosis; endometrium; female; genetic polymorphism; genetics; human
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Mukhotib Mukhotib
Date Deposited: 20 May 2024 04:09
Last Modified: 20 May 2024 04:09
URI: https://ir.lib.ugm.ac.id/id/eprint/1288

Actions (login required)

View Item
View Item