Prevalence of and factors associated with postnatal depression and anxiety among parents of preterm infants: A systematic review and meta-analysis

Background: This study aimed to determine the prevalence of and factors associated with postpartum depression and anxiety among mothers and fathers of preterm infants and to examine the relationships between maternal and paternal symptoms. Methods: Six electronic databases were searched to identify eligible studies reporting parental depression and anxiety within 1 year postpartum. Data were extracted for a random-effects meta-analysis to estimate the prevalence with 95 confidence intervals (CIs). Subgroup and meta-regression analyses were conducted to analyze associations between study characteristics and prevalence estimates. Results: In total, 79 studies were included. The meta-analysis of studies on mothers generated estimates of prevalence for depression (29.2 , 95 CI, 21.8 –37.9 ) and anxiety (37.7 , 95 CI, 24.1 –53.6 ). The meta-analysis of fathers indicated a pooled depression prevalence of 17.4 (95 CI, 12.5 –23.8 ) and an anxiety estimate of 18.3 (95 CI, 8.1 –36.3 ). Assessment time points and methods as well as the geographic continent in which the study was conducted were significant moderators of depression and anxiety. Significant inter-correlations were found between mothers' and fathers' depression and anxiety symptoms (p < 0.05). Limitations: Limited data from specific geographic continents, including Africa and Asia. Conclusions: Prevalence of depression and anxiety among preterm infants' parents was high, highlighting the need for early psychological screening and assessment. Further research is required to improve services that focus on parents' postpartum psychological needs in the family context. © 2022