Circumcision in subject with hemophilia: the Yogyakarta Method

Widjajanto, Pudjo Hagung and Wibowo, Agus and Saputro, Ivan Onggo and Budiono, Nur and Hadi, Nurul and Tusino, Agus and Sutowo, David Wijaya (2024) Circumcision in subject with hemophilia: the Yogyakarta Method. Paediatrica Indonesiana(Paediatrica Indonesiana), 64 (3). pp. 242-247. ISSN 00309311

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Abstract

Background Circumcision is one of the most common surgical procedures in boys in Indonesia. In cases patient with hemophilia (PWH), doctors tend to avoid this procedure due to increased bleeding tendency. In 2007, we developed a protocol for clotting factor concentrate (CFC) administration for circumcision in PWH, namely, the “Yogyakarta Method.” Objective To evaluate the outcomes of the Yogyakarta Method for circumcising PWH. Methods This descriptive study was based on medical records of PWH who underwent circumcision at Dr. Sardjito Hospital (DSH), Yogyakarta and 3 surrounding hospitals under DSH super-vision from 2008-2017 and 2018-2022. Diagnoses of hemophilia were based on clinical findings and factor assays. Subjects with hemophilia A received factor VIII (25 IU/kg/dose) and those with hemophilia B received factor IX (50 IU/kg/dose) before, during and after the procedure. In addition, patients received tranexamic acid (15 mg/kg/dose). Circumcision was performed by a pediatric surgeon or urologist. Results From 2008-2017, 28 PWH underwent circumcision, 14/28 of whom were in DSH. Twenty-six patients had hemophilia A and 2 had hemophilia B. Their severities were mild (12 subjects), moderate (10 subjects), and severe (6 subjects). Subjects’ median age was 10.5 (5-19) years and their median CFC use was 8 (range 7-10) doses in hemophilia A and 4 (range 4-5) doses in hemophilia B patients. Three of 28 PWH had bleeding episodes after the procedure. Fol-lowing the encouraging results from the initial 2008-2017 study period, most of PWH circumcised in 2018-2022 underwent the procedure in the same 3 district hospitals rather than at DSH (21/28 subjects), and had similar CFC consumption. Only 1 bleeding episode occurred after the procedure during the second study period. Conclusion The Yogyakarta method is safe and sufficient to control bleeding in circumcision of PWH. This method is also suitable in a district hospital setting. © 2024, Indonesian Pediatric Society Publishing House. All rights reserved.

Item Type: Article
Additional Information: Cited by: 0
Uncontrolled Keywords: circumcision; hemophilia; clotting factor concentrates; district hospital
Subjects: R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Ngesti Gandini
Date Deposited: 13 Mar 2025 01:17
Last Modified: 13 Mar 2025 01:17
URI: https://ir.lib.ugm.ac.id/id/eprint/15732

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