Efficacy and Safety Profile of Tuberculin Protein Purified Derivative Injection As Immunotherapy For the Treatment of Cutaneous and Anogenital Warts: A Review Article

Achdiat, Pati Aji and Suwarsa, Oki and Hidayat, Yudi Mulyana and Shafiee, Mohamad Nasir and Dwiyana, Reiva Farah and Hindritiani, Reti and Sutedja, Endang and Pudjiati, Satiti Retno and Hilmanto, Dany and Dhamayanti, Meita and Parwati, Ida and Maharani, Retno Hesty and Sutedja, Eva Krishna and Avriyanti, Erda and Yunitasari, Yunitasari (2024) Efficacy and Safety Profile of Tuberculin Protein Purified Derivative Injection As Immunotherapy For the Treatment of Cutaneous and Anogenital Warts: A Review Article. ImmunoTargets and Therapy, 13. 123 -150. ISSN 22531556

[thumbnail of 452.pdf] Text
452.pdf - Published Version
Restricted to Registered users only
Available under License Creative Commons Attribution.

Download (1MB) | Request a copy

Abstract

Introduction: Various treatments available today for anogenital and cutaneous warts have limitations, including time-consuming, challenging to perform, and the risk of scarring. A new treatment using tuberculin purified protein derivative (PPD) has been developed, which is expected to generate cellular immunity against HPV. Objective: To assess the evidence for the efficacy and safety of PPD treatment for cutaneous and anogenital warts. Materials and methods: A literature search was performed with the keyword-based search on digital libraries, including the National Library of Medicine, Cochrane Controlled Register of Trial, and Google Scholar, using the following terms: anogenital warts, condyloma acuminata, cutaneous warts, human papillomavirus, immunotherapy, and tuberculin purified protein derivative. Original studies on treating cutaneous or anogenital warts with PPD were included. The results were 47 clinical trials and 4 case reports. Most of the research was done in countries with common Mycobacterium tuberculosis infection. The treatment showed good efficacy. Comparative studies showed that the treatment has similar efficacy with other immunotherapies. No significant side effects were reported, with evidence of the safety use on the pregnant population. Conclusion: Based on good efficacy and safety, PPD can be considered an alternative therapy, especially in countries where tuberculosis is frequent. © 2024 Achdiat et al.

Item Type: Article
Additional Information: Cited by: 2; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: tuberculin; condyloma acuminatum; data analysis; data extraction; data quality; data quality assessment; drug efficacy; drug safety; human; immunotherapy; information processing; information retrieval; protein purification; Review; wart
Subjects: R Medicine > RL Dermatology
Divisions: Faculty of Medicine, Public Health and Nursing > Non Surgical Divisions
Depositing User: Mukhotib Mukhotib
Date Deposited: 14 Mar 2025 03:07
Last Modified: 14 Mar 2025 03:07
URI: https://ir.lib.ugm.ac.id/id/eprint/15747

Actions (login required)

View Item
View Item