Novel Approach for Evaluating Pregnancy-Associated Glycoprotein and Inflammation Markers during the Postpartum Period in Holstein Friesian Cows

Priyo, Jr, Topas Wicaksono and Edo, Ayane and Taura, Yasuho and Yamato, Osamu and Ono, Tetsushi and Taniguchi, Masayasu and Widodo, Oky Setyo and Islam, Md Shafiqul and Maki, Shinichiro and Takagi, Mitsuhiro (2024) Novel Approach for Evaluating Pregnancy-Associated Glycoprotein and Inflammation Markers during the Postpartum Period in Holstein Friesian Cows. Animals, 14 (10): 1459. pp. 1-14. ISSN 20762615

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Abstract

We evaluated the relationship between decreased pregnancy-associated glycoprotein (PAG) levels, inflammatory parameters (serum amyloid A [SAA] and milk amyloid A [MAA]), postpartum inflammatory conditions (mastitis, ketosis, and follicular cysts), and the FOXP3 gene. Nineteen Holstein-Friesian cows were included in this study. Up to approximately eight weeks after delivery, weekly health examinations were performed for mastitis and ketosis, and reproductive organ ultrasonography was performed. The decreasing PAG rate was negatively correlated with SAA concentration (r = −0.493, p = 0.032). Cows with mastitis exhibited a slower trend of PAG decrease (p = 0.095), and a greater percentage of these cows had MAA concentrations above 12 µg/mL (p = 0.074) compared with those without mastitis. A negative correlation, although nonsignificant (r = −0.263, p = 0.385), was observed between the day-open period and decreased PAG rate. The day-open period was correlated with the presence or absence of follicular cysts (p = 0.046). Four cows that developed follicular cysts were homozygous for the G allele of the FOXP3 gene related to repeat
breeders. These results indicate a relationship between a decreased PAG rate and inflammatory status during the postpartum period. Thus, suppressing inflammation during the perinatal period may improve reproductive efficiency in the dairy industry.

Item Type: Article
Uncontrolled Keywords: Holstein Friesian; FOXP3 gene; pregnancy-associated glycoprotein; serum amyloid A; milk amyloid A
Subjects: Veterinary Medicine
Divisions: Faculty of Veterinary Medicine
Depositing User: Erlita Cahyaningtyas Cahyaningtyas
Date Deposited: 14 Mar 2025 03:20
Last Modified: 14 Mar 2025 03:20
URI: https://ir.lib.ugm.ac.id/id/eprint/15756

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