Donato, Celeste M. and Handley, Amanda and Byars, Sean G. and Bogdanovic-Sakran, Nada and Lyons, Eleanor A. and Watts, Emma and Ong, Darren S. and Pavlic, Daniel and Thobari, Jarir At and Satria, Cahya Dewi and Nirwati, Hera and Soenarto, Yati and Bines, Julie E. (2024) Vaccine Take of RV3-BB Rotavirus Vaccine Observed in Indonesian Infants Regardless of HBGA Status. Journal of Infectious Diseases, 229 (4). pp. 1010-1018. ISSN 00221899
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Abstract
Background. Histo-blood group antigen (HBGA) status may affect vaccine efficacy due to rotavirus strains binding to HBGAs in a P genotype–dependent manner. This study aimed to determine if HBGA status affected vaccine take of the G3P6 neonatal vaccine RV3-BB. Methods. DNA was extracted from stool samples collected in a subset (n = 164) of the RV3-BB phase IIb trial in Indonesian infants. FUT2 and FUT3 genes were amplified and sequenced, with any single-nucleotide polymorphisms analyzed to infer Lewis and secretor status. Measures of positive cumulative vaccine take were defined as serum immune response (immunoglobulin A or serum-neutralizing antibody) and/or stool excretion of RV3-BB virus. Participants were stratified by HBGA status and measures of vaccine take. Results. In 147 of 164 participants, Lewis and secretor phenotype were determined. Positive vaccine take was recorded for 144 (97.9%) of 147 participants with the combined phenotype determined. Cumulative vaccine take was not significantly associated with secretor status (relative risk, 1.00 95% CI, .94–1.06; P = .97) or Lewis phenotype (relative risk, 1.03 95% CI, .94–1.14; P = .33), nor was a difference observed when analyzed by each component of vaccine take. Conclusions. The RV3-BB vaccine produced positive cumulative vaccine take, irrespective of HBGA status in Indonesian infants. © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Item Type: | Article |
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Additional Information: | Cited by: 0; All Open Access, Green Open Access, Hybrid Gold Open Access |
Uncontrolled Keywords: | blood group antigen; histo blood group antigen; neutralizing antibody; Rotavirus vaccine; unclassified drug; antibody titer; Article; controlled study; DNA extraction; FUT2 gene; FUT3 gene; gene; gene frequency; genotyping; human; immune response; immunogenicity; major clinical study; missense mutation; newborn; phase 2 clinical trial (topic); phenotype; randomized controlled trial (topic); reverse transcription polymerase chain reaction; single nucleotide polymorphism |
Subjects: | R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services R Medicine > RM Therapeutics. Pharmacology |
Divisions: | Faculty of Medicine, Public Health and Nursing > Non Surgical Divisions |
Depositing User: | Ngesti Gandini |
Date Deposited: | 17 Mar 2025 04:46 |
Last Modified: | 17 Mar 2025 04:46 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/15779 |