The Yield of Active Tuberculosis Disease and Latent Tuberculosis Infection in Tuberculosis Household Contacts Investigated Using Chest X-ray in Yogyakarta Province, Indonesia

Nababan, Betty and Triasih, Rina and Chan, Geoffrey and Dwihardiani, Bintari and Hidayat, Arif and Dewi, Setyogati C. and Unwanah, Lana and Mustofa, Arif and du Cros, Philipp (2024) The Yield of Active Tuberculosis Disease and Latent Tuberculosis Infection in Tuberculosis Household Contacts Investigated Using Chest X-ray in Yogyakarta Province, Indonesia. Tropical Medicine and Infectious Disease, 9 (2). pp. 1-10. ISSN 24146366

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Abstract

In Indonesia, the implementation of tuberculosis (TB) contact investigation is limited, with low detection rates. We report the yield of and risk factors for TB disease and infection for household contacts (HHCs) investigated using chest X-ray (CXR) screening. We identified HHCs aged five years and above of bacteriologically confirmed index cases from 2018 to 2022 in Yogyakarta City and Kulon Progo. All HHCs were offered screening for TB symptoms; TB infection testing with either tuberculin skin testing or interferon gamma release assay; and referral for CXR. Sputum from those with symptoms or CXR suggestive of TB was tested with Xpert MTB/RIF. Risk factors for active TB disease and latent TB infection (LTBI) were identified by logistic regression models. We screened 2857 HHCs for TB between June 2020 and December 2022, with 68 (2.4) diagnosed with active TB. Of 2621 HHCs eligible for LTBI investigation, 1083 (45.7) were diagnosed with LTBI. The factors associated with active TB were age, being underweight, diabetes mellitus, urban living, and sleeping in the same house as an index case. Factors associated with LTBI were increasing age and male gender. Conclusions: Screening for HHC including CXR and TST/IGRA yielded a moderate prevalence of TB disease and infection. © 2024 by the authors.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: adult; Article; controlled study; diabetes mellitus; diagnostic value; disease duration; female; household; human; Indonesia; interferon gamma release assay; latent tuberculosis; major clinical study; male; obesity; population density; risk factor; skin test; sleep; sputum; thorax radiography; tuberculosis; underweight; venous blood
Subjects: R Medicine > RP Public Health and Nutrition
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine, Public Health and Nursing > Non Surgical Divisions
Depositing User: Ngesti Gandini
Date Deposited: 18 Mar 2025 02:42
Last Modified: 18 Mar 2025 02:42
URI: https://ir.lib.ugm.ac.id/id/eprint/15807

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