Association between the Melanocortin-4 Receptor (MC4R) Gene Polymorphisms and Growth Trait in Sumba Ongole Cattle

Melanocortin-4 receptor (MC4R) gene has been known as a candidate gene for growth traits in livestock.
This research was aimed to identify the polymorphism of MC4R gene and its association with growth traits
in Sumba Ongole (SO) cattle. The growth traits data consist of body weight and body size. Eighty four
blood samples were collected and used for DNA isolation. The results showed one SNP (g.1133C>G) re-
sulting in two alleles (C and G) and three genotypes (CC, CG, and GG) in SO cattle. The frequency of G
allele (0.59) was higher than C allele (0.41). The CG genotype had the highest value of genotype frequency
(0.48). The allele and genotype distributions followed the Hardy-Weinberg equilibrium. The single nucleo-tide polymorphism (SNP) g.1133C > G revealed having no significant association with growth traits in SO
cattle. In conclusion, the SNP g.1133C > G may not useful as selection tool in Sumba Ongole cattle. It can
be suggested that the future study is needed to find out the effect of the MC4R gene in Sumba Ongole cattle
in different locus.