In vivo study: The effects of Carica pubescens seed extract on the anthelmintic activity, feed digestibility, performance, and clinical parameters of thin-tailed sheep

This research serves to follow up on the results of an in vivo study of the administration of aqueous seed extract (ASE) of Carica pubescens waste on the performance and health parameters of thin-tailed sheep. This research was conducted at Al Baihaqi farm in Kediri, East Java. Thirty-two thin-tailed sheep aged 12 months were randomly given four treatments with P0 = negative control, P1 = 2.5 ASE, P2 = 5 ASE, and P4 = positive control (Albendazole). This study used sheep that were naturally exposed to Haemonchus contortus (from the farmer's field) with the epg qualification being above 1000. The in vivo study was carried out for 9 weeks with the administration of Carica seed extract on the initial 7 days in a row, and the positive control was given Albendazole once on the seventh day. The number of ASE grants was based on the average fluid in the abomasum per kg of body weight. The feed design used in this study was wheat bran and Pennisetum purpureum cv. Mott according to the livestock's needs. The data taken in this study were the feed consumption, digestibility, average daily gain, percent fecal egg count reduction, body condition score, and clinical parameters. The results showed that the FECR, ADG, and clinical parameters (AST and ALT) (P>0.05) underwent significant changes to support good performance while the BUN, creatinine, feed consumption, and digestibility were normal. This study indicates that ASE of up to 5 can be used as an anthelmintic alternative and support the recovery of sheep performance. © Published under licence by IOP Publishing Ltd.