Diagnostic Accuracy of Ultrasound in Cholestatic Infants with Biliary Atresia

Arsena, Hermis and Tedja, Audric Kenny and Gunarti, Hesti and Leksono, Tiara Putri and Kuncoro, Afina Azka Latifanisa and Amaragati, Adisrasti Rejeki and Makhmudi, Akhmad and Gunadi, Gunadi (2024) Diagnostic Accuracy of Ultrasound in Cholestatic Infants with Biliary Atresia. Turkish Archives of Pediatrics, 59 (5). pp. 449-453. ISSN 27576256

[thumbnail of Diagnostic Accuracy of Ultrasound in Cholestatic Infants with Biliary Atresia.pdf] Text
Diagnostic Accuracy of Ultrasound in Cholestatic Infants with Biliary Atresia.pdf - Published Version
Restricted to Registered users only
Available under License Creative Commons Attribution Non-commercial.

Download (2MB) | Request a copy

Abstract

Objective: Biliary atresia (BA) is an obstructive cholangiopathy that involves the intrahepatic and extrahepatic bile ducts. Ultrasound (US) can aid in evaluation of the biliary system and be efficiently used in daily practice. However, most studies on US for diagnosing BA have been conducted in developed countries. Therefore, we have aimed to evaluate the diagnostic accuracy of US in BA in infants with cholestasis from a developing country. Materials and Methods: This retrospective study used data collected from our hospital medical records. The US findings were compared with the gold standard intraoperative or cholangiography findings. Results: Thirty-five BA patients (19 males and 16 females) and 36 controls (20 males and 16 females) were included in the study. Most of the patients (85.7) were ≤ 6 months old. The absence of a gallbladder demonstrated 71.42 sensitivity (Sn), 91.67 specificity (Sp), 89.29 positive predictive value (PPV), 76.74 negative predictive value (NPV), 8.57 positive likelihood ratio (LR+), and 0.31 negative likelihood ratio (LR−) for diagnosing BA. The triangular cord sign demonstrated 14.28 Sn, 100 Sp, 100 PPV, 76.74 NPV, ∞ LR+, and 0.86 LR-for diagnosing BA. The combination of gallbladder absence and a positive triangular cord sign demonstrated 82.85 Sn, 91.67 Sp, 90.63 PPV, 84.61 NPV, 9.95 LR+, and 0.19 LR− for diagnosing BA. Conclusion: The diagnostic accuracy of US in BA is high, indicating that it can be the imaging tool of choice in infants with cholestasis. Ultrasound is safe and can be easily used in daily practice without the risk of radiation exposure. © 2024, AVES. All rights reserved.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Article; bile duct atresia; cholangiography; cholestasis; clinical observation; controlled study; developing country; diagnostic accuracy; diagnostic test accuracy study; early diagnosis; echography; female; gallbladder; general pathological parameters; gold standard; human; infant; intraoperative period; liver biopsy; male; negative likelihood ratio; positive likelihood ratio; predictive value; retrospective study; sensitivity and specificity; triangular cord sign
Subjects: R Medicine > RD Surgical Divisions
Divisions: Faculty of Medicine, Public Health and Nursing > Surgical Divisions
Depositing User: Ani PURWANDARI
Date Deposited: 03 Jul 2025 09:06
Last Modified: 03 Jul 2025 09:06
URI: https://ir.lib.ugm.ac.id/id/eprint/19369

Actions (login required)

View Item
View Item