In Vitro Anthelmintic Activity of Tectona grandis Linn. Leaves Nanoemulsion

Indriati, Dian and Erista, Yulita Nadzifa and Widiyono, Irkham and Baihaq, Zein Ahmad and Yanuartono, Yanuartono (2025) In Vitro Anthelmintic Activity of Tectona grandis Linn. Leaves Nanoemulsion. Journal of Animal Health and Production, 13 (2). 346 -354. ISSN 23082801

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Abstract

Frequent use of pharmaceutical anthelmintic has resulted in a marked increase in anthelmintic resistance. This resistance is characterized by the inherited reduction in sensitivity of a parasite population to an anthelmintic that was previously effective against it. This study aimed to evaluate the potential of Tectona grandis (teak) leaf nanoemulsion as a bioanthelmintic. The nanoemulsion was prepared using leaves of T. grandis grown in Gunungkidul, Yogyakarta. The anthelmintic effect was assessed through an in vitro mortality test on Haemonchus sp. worms and analyzed using scanning electron microscopy. Observations were made at 0.5 hours, 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, and 12 hours during the in vitro mortality test of Haemonchus sp. worms. A one-way analysis of variance (ANOVA)
was performed, followed by Duncan’s test to determine significant differences. The results of the in vitro study indicated that concentrations of 3%, 5%, and 7% of T. grandis Linn. leaf nanoemulsion inhibited Haemonchus sp., with the 7% concentration causing the death of all adult Haemonchus sp. worms by the 4th hour. Scanning electron microscopy analysis of the nanoemulsion revealed damage to the cuticle structures of the worms. The inclusion of up to 7% T. grandis leaf nanoemulsion may serve as a promising alternative for combating Haemonchus sp.

Item Type: Article
Uncontrolled Keywords: Anthelmintic, Haemonchus sp, Nanoemulsion, Tectona grandis linn, Secondary metabolite, Mortality
Subjects: Veterinary Medicine
Divisions: Faculty of Veterinary Medicine
Depositing User: Erlita Cahyaningtyas Cahyaningtyas
Date Deposited: 08 Jul 2025 06:23
Last Modified: 08 Jul 2025 06:23
URI: https://ir.lib.ugm.ac.id/id/eprint/19682

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