Risk Factors of Early Complications in Pediatric Biliary Atresia After Kasai Procedure in Dr. Sardjito Hospital

Introduction: Biliary atresia is progressive fibroinflammation cholangiopathy which may cause death if not treated immediately. Hepatoportoenterostomy Kasai procedure is used to recover hepatic biliary flow to the intestine. There are various complications after Kasai procedure, ranging from cholangitis to common complications such as sepsis. Early complications which arise during intensive care need attention, since it may increase mortality and morbidity. Factors such as age, sex, ASA physical state, nutritional state, perioperative anemia, blood transfusion, congenital heart disease, hypoalbumin, supportive drug usage, and acute CMV infection may be related to early complications after Kasai procedure. Methods: This study used case control method to determine contributing factors to postoperative complications after Kasai procedure. The affordable population is biliary atresia pediatric patients who underwent Kasai procedure and admitted to the intensive ward at Dr. Sardjito General Hospital within the period of January 1st 2016 until December 31st 2021. Variables suspected of having contributions with postoperative complications after Kasai procedure was tested using chi square test or Fisher's exact test. These variables then further tested using multivariable logistic regression test. Results: The most frequent complication out of 52 samples was sepsis (77,27). ASA physical state and perioperative anemia had significant results and was considered as independent variables with postoperative complications after Kasai procedure (p<0.05). Conclusion: ASA physical state III-IV and perioperative anemia was contributed in postoperative complications occurrence, in which patient with ASA physical state III-IV is more susceptible to complications by 10 times, while patient with perioperative anemia is 4 times more susceptible to postoperative complications. © 2024 Universiti Putra Malaysia Press. All rights reserved.