Prognostic Variables for Colorectal Cancer Patients' Survival in Indonesia

Introduction: Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. Several prognostic factors have influenced the survival of CRC patients, including NLR and age. We determined the survival of CRC patients and associated it with the prognostic factors. Methods: A retrospective study was performed using the medical records of CRC patients who underwent surgery at our institution from January 2014 to December 2018. Results: The overall survival of our 34 CRC patients was 67.6. The area under the ROC curve and cut-off level of age and neutrophil to lymphocyte ratio (NLR) for the survival of patients with CRC was 0.644 and 63 years old, and 0.648 and 5.09, respectively. Log-rank analysis showed a significant association between the age, staging, neutrophil, and NLR and the survival of CRC patients (p=0.001, 0.014, 0.008, and 0.0006, respectively). while the sex, tumor grade, and lymphocyte were not (p=0.292, 0.084, and 0.115, respectively). Multivariate analysis revealed that age, tumor grade, and NLR were the strong independent factors for the CRC patients' survival with a hazard ratio of 38.72 (95 CI=3.48-430.97; p=0.003), 28.85 (95 CI=2.14-389.85; p=0.011), and 24.87 (95 CI=2.62-235.76; p=0.005), respectively. Conclusion: Our study shows that the overall survival rate of our CRC patients is considered good. Age, tumor grade, and NLR strongly predict the survival of patients with CRC. These findings imply that a simple method, i.e., higher NLR, can predict the poor prognosis of CRC patients. Attending surgeons might consider those prognostic factors during the counseling before surgery with the patients and families. © 2024 Universiti Putra Malaysia Press. All rights reserved.