Increased serum activin A level in congenital heart disease-associated pulmonary artery hypertension: A comparative study from the COHARD-PH registry

Hadwiono, Muhammad R. and Hartopo, Anggoro B. and Wasityastuti, Widya and Anggrahini, Dyah W. and Ryanto, Gusty R. T. and Emoto, Noriaki and Dinarti, Lucia K. (2023) Increased serum activin A level in congenital heart disease-associated pulmonary artery hypertension: A comparative study from the COHARD-PH registry. Pulmonary Circulation, 13 (3). ISSN 20458932

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Abstract

Activin A, a member of TGF-β superfamily, has been implicated in the pathogenesis of pulmonary artery hypertension (PAH). PAH due to congenital heart disease (CHD-PAH) is a major problem in developing countries. Activin A may have a role in PAH development and progression among uncorrected CHD. In this comparative study, serum activin A level was significantly increased in subjects with uncorrected CHD without the presence of PH and were more significantly risen in CHD-PAH, as compared to control. The utilization of serum activin A measurement seems promising to identify uncorrected CHD patients with PAH development and progression. © 2023 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: activin A; amino terminal pro brain natriuretic peptide; biological marker; endothelin 1; adult; blood sampling; body mass; comparative study; congenital heart disease; controlled study; cross-sectional study; disease severity; echocardiography; electrochemiluminescence immunoassay; female; heart atrium septum defect; heart left ventricle ejection fraction; hemodynamics; human; Letter; lung artery pressure; pulmonary hypertension; tricuspid annular plane systolic excursion
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Annisa Fitria Nur Azizah Annisa Fitria Nur Azizah
Date Deposited: 29 May 2024 07:14
Last Modified: 29 May 2024 07:14
URI: https://ir.lib.ugm.ac.id/id/eprint/2358

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