Hadwiono, Muhammad R. and Hartopo, Anggoro B. and Wasityastuti, Widya and Anggrahini, Dyah W. and Ryanto, Gusty R. T. and Emoto, Noriaki and Dinarti, Lucia K. (2023) Increased serum activin A level in congenital heart disease-associated pulmonary artery hypertension: A comparative study from the COHARD-PH registry. Pulmonary Circulation, 13 (3). ISSN 20458932
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Abstract
Activin A, a member of TGF-β superfamily, has been implicated in the pathogenesis of pulmonary artery hypertension (PAH). PAH due to congenital heart disease (CHD-PAH) is a major problem in developing countries. Activin A may have a role in PAH development and progression among uncorrected CHD. In this comparative study, serum activin A level was significantly increased in subjects with uncorrected CHD without the presence of PH and were more significantly risen in CHD-PAH, as compared to control. The utilization of serum activin A measurement seems promising to identify uncorrected CHD patients with PAH development and progression. © 2023 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
Item Type: | Article |
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Additional Information: | Cited by: 0; All Open Access, Gold Open Access, Green Open Access |
Uncontrolled Keywords: | activin A; amino terminal pro brain natriuretic peptide; biological marker; endothelin 1; adult; blood sampling; body mass; comparative study; congenital heart disease; controlled study; cross-sectional study; disease severity; echocardiography; electrochemiluminescence immunoassay; female; heart atrium septum defect; heart left ventricle ejection fraction; hemodynamics; human; Letter; lung artery pressure; pulmonary hypertension; tricuspid annular plane systolic excursion |
Subjects: | R Medicine > RC Internal medicine |
Divisions: | Faculty of Medicine, Public Health and Nursing > Biomedical Sciences |
Depositing User: | Annisa Fitria Nur Azizah Annisa Fitria Nur Azizah |
Date Deposited: | 29 May 2024 07:14 |
Last Modified: | 29 May 2024 07:14 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/2358 |