Impact of Men with Undescended Testis on Fertility and Hormonal Function Promoting Hypogonadism

Yuri, Prahara and Wenang, Supriyatiningsih and Febrianti, Lidia and Dewi, Arlina and Rizal, Dicky Moch and Lelle, Ralph J. (2023) Impact of Men with Undescended Testis on Fertility and Hormonal Function Promoting Hypogonadism. Bangladesh Journal of Medical Science, 22 (4). pp. 859-868. ISSN 22234721

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Abstract

Objectives: Undescended testes or cryptorchidism is a disorder in men and is associated with hypogonadism and infertility. UDT is the majority factor in male adults. Studies on the effects of UDT on hormone-associated hypogonadism are limited. Materials and Methods: This study aimed to assess the effects of UDT on fertility and testicular hormonal function in adult men. Data from medical records were gathered, laboratory tests, and retrospective interviews from 2018 to 2020. The independent variable was men with UDT, while the dependent variable was fertility and reproductive hormones that trigger hypogonadism. Data on infertility, reproductive hormones, semen analysis, and symptoms of hypogonadism from 20 patients with and without UDT. ANOVA, Kruskal-Wallis test, Pearson chi-square test, and Fisher’s exact test helped perform the analysis. Results and Discussion: Undescended testes were associated with infertility so that levels of FSH and LH were considerably greater than men without UDT (p < 0.05). Bilateral UDT men had the highest levels of FSH and LH but not significantly different from unilateral UDT (p > 0.05). Bilateral UDT men had the lowest mean estradiol, testosterone and sperm quality (p < 0.05). All men had prolactin and AMH levels within normal limits (p > 0.05). Men with UDT had more significant hypogonadal symptoms (p < 0.001) Conclusion: Infertility, FSH, and LH levels were highest in men with bilateral UDT, but testosterone and estradiol levels were lowest. It also has the worst sperm quality and the most hypogonadal symptoms. All of the men had normal prolactin and AMH levels. © 2023, Ibn Sina Trust. All rights reserved.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access
Uncontrolled Keywords: estradiol; follitropin; prolactin; testosterone; Article; body mass; clinical article; cross-sectional study; cryptorchism; endocrine function; enzyme linked immunosorbent assay; fertility; human; hypogonadism; immunofluorescence assay; infertility; male; medical record; retrospective study; semen analysis; sperm count; sperm quality; spermatozoon motility
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Agricultural Technology > Food and Agricultural Product Technology
Depositing User: Annisa Fitria Nur Azizah Annisa Fitria Nur Azizah
Date Deposited: 30 May 2024 01:39
Last Modified: 30 May 2024 01:39
URI: https://ir.lib.ugm.ac.id/id/eprint/2369

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