Correlation Between Cardiac Index, Plasma Troponin I, Myocardial Histopathology, CPB and AoX Duration in Glutamine versus No Glutamine Administered Patients with Low Ejection Fraction Undergoing Elective On-Pump CABG Surgery: Secondary Analysis of an RCT

Parmana, I Made Adi and Boom, Cindy Elfira and Rachmadi, Lisnawati and Hanafy, Dudy Arman and Widyastuti, Yunita and Mansyur, Muchtaruddin and Siswanto, Bambang Budi (2023) Correlation Between Cardiac Index, Plasma Troponin I, Myocardial Histopathology, CPB and AoX Duration in Glutamine versus No Glutamine Administered Patients with Low Ejection Fraction Undergoing Elective On-Pump CABG Surgery: Secondary Analysis of an RCT. Vascular Health and Risk Management, 19. pp. 93-101. ISSN 11766344

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Abstract

Purpose: On-pump coronary artery bypass graft (CABG) causes myocardial ischemia, through the cardiopulmonary bypass (CPB) and aortic cross-clamping (AoX). Glutamine supplementation protects cardiac cells during cardiac ischemia. This study analysed the correlation between cardiac index (CI), plasma troponin I, myocardial histopathology, CPB and AoX duration in low ejection fraction patients receiving glutamine and no glutamine undergoing elective on-pump CABG. Material and Methods: This was a secondary analysis of a double-blind, randomised controlled trial of 60 patients, split into control and intervention (glutamine) groups. Glutamine was administered at a dose of 0.5 g/kg/24 hours. There were 29 patients in each respective groups after a total of two patients dropped out. Results: A negative correlation (p = 0.037) was observed between CPB duration and CI at 6 hours after CPB in the glutamine group. A positive correlation (p = 0.002) was also observed between AoX duration and plasma troponin I at 6 hours after CPB in the control group. However, no correlation was observed between myocardial histopathology and plasma troponin I level at 5 minutes after CPB. Conclusion: Significant negative correlation between CPB duration and CI at 6 hours after CPB in the glutamine group, along with significant positive correlation between AoX duration and plasma troponin I level at 6 hours after CPB in the control group demonstrated the myocardial protection qualities of intravenous glutamine administration in patients with low ejection fraction undergoing elective on-pump CABG surgeries. © 2023 Parmana et al.

Item Type: Article
Additional Information: Cited by: 1; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Disease; Humans; Myocardial Ischemia; Myocardium; Stroke Volume; Troponin I; glutamine; troponin I; troponin I; adult; aortic clamping; apoptosis index; Article; blood analysis; blood sampling; cardiac index; cardiopulmonary bypass; comparative study; controlled study; coronary artery bypass graft; correlational study; double blind procedure; female; heart ejection fraction; heart muscle injury; heart protection; heart tissue; histopathology; human; human tissue; major clinical study; middle aged; on pump coronary artery bypass graft; patient dropout; protein blood level; randomized controlled trial; secondary analysis; adverse event; cardiac muscle; cardiopulmonary bypass; coronary artery bypass graft; coronary artery disease; heart muscle ischemia; heart stroke volume
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Ngesti Gandini
Date Deposited: 05 Jun 2024 06:37
Last Modified: 05 Jun 2024 06:37
URI: https://ir.lib.ugm.ac.id/id/eprint/2418

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