Preparation and Characterization of Local Indonesian Chitosan-graft-Maleic Anhydride as Drug Carrier

The modification of local Indonesian chitosan as a drug carrier is conducted by grafting with maleic anhydride (MA). The grafted film resulting in a negative charge of carboxyl group attach on chitosan backbone. Several ratio of MA/chitosan is conducted to evaluate the effect of MA on the drug release behavior. Chitosan and MA was dissolved and stirred in 1 (v/v) acetic acid for 24 hours. Tween 80 and curcumin are added to the solution as surfactant and drug model respectively. The homogeneous solution is casted into polyethylene petri dish and dried under room temperature. Chitosan-graft-MA is characterized by Fourier Transform Infra-Red (FTIR) in addition to gravimetric titration to characterize the existing of carboxyl groups of the films. The swelling and degradation ability in phosphate buffered saline (PBS) solution is showed an increasing trend as the addition of MA. The kinetic study of drug release is performed in Peppas and first order model. An optimum condition of grafting is achieved at 150 (w/w).