Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome

Dewi, Shinta Trilaksmi and Qomariah, Laily Noor and Sarkowi, Widya Khairunisa and Puspitasari, Monika and Khalidah, Miya and Anggatama, Marcella and Rizkiani, Dwinanda Almira and Etnawati, Kristiana and Febriana, Sri Awalia (2023) Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome. Dermatology Reports, 15 (2): 9656. 01-05. ISSN 20367392

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Abstract

The treatment of epidermal necrolysis in pediatric patients remains a major challenge. Cyclosporine A has emerged as a promising therapy for epidermal necrolysis in adults; however, its efficacy in children is unclear. We present the case of a boy with Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome who was initially resistant to methylprednisolone monotherapy but improved after receiving the combination of cyclosporine A and methylprednisolone. Published reports on the use of cyclosporine A for pediatric epidermal necrolysis are also briefly reviewed. ©Copyright: the Author(s), 2023.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: antibiotic agent; C reactive protein; chlorpheniramine maleate; cyclosporine; methylprednisolone; paracetamol; Article; blister; body surface; case report; child; clinical article; conjunctivitis; coughing; epidermolysis; epithelization; erosion; face; fever; hospital admission; hospitalization; human; leukopenia; limb; male; mortality risk; neck; rash; school child; serology; skin defect; Stevens Johnson/toxic epidermal necrolysis overlap syndrome; stomatitis; trunk
Subjects: R Medicine > RC Internal medicine
R Medicine > RL Dermatology
Divisions: Faculty of Medicine, Public Health and Nursing > Non Surgical Divisions
Depositing User: Ngesti Gandini
Date Deposited: 20 Jun 2024 02:47
Last Modified: 20 Jun 2024 02:47
URI: https://ir.lib.ugm.ac.id/id/eprint/2659

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