The effect of oral anticoagulant use before visit for patients with COVID-19 on mortality: A meta-analysis

Ghea, Cornelia and Wardhana, Ardyan and Nugroho, Alfredo and Assilmi, Fika Humaeda (2023) The effect of oral anticoagulant use before visit for patients with COVID-19 on mortality: A meta-analysis. Tzu Chi Medical Journal, 35 (3). pp. 226-230. ISSN 10163190

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Abstract

Objectives: Anticoagulants have been used as therapeutic or prophylactic agents in COVID-19 and seem to be more beneficial. However, the advantage of oral anticoagulant (OAC) consumption before visit in lowering mortality in COVID-19 patients remains debatable. This meta-analysis aimed to evaluate the effect of OAC use before visit on mortality using the hazard ratio (HR) to estimate the effect of time-to-event endpoints. Materials and Methods: We conducted a literature search in the PubMed and ProQuest databases for any studies comparing groups consuming OAC to no-OAC before visit for mortality in patients with COVID-19. We calculated the overall HRs and their variances across the studies using the random-effects model to obtain pooled estimates. Results: We included 12 studies which had sample sizes ranging from 70 to 459,402 patients. A meta-analysis comparing OAC therapy and non-OAC consumption in COVID-19 patients before visit revealed no decrease in all-cause mortality (HR = 0.92, 95 confidence interval CI: 0.83-1.02, P = 0.12; I 2 = 68%). However, subgroup analysis of laboratory-confirmed populations revealed that OAC use before visit had a beneficial effect on mortality (HR = 0.84, 95% CI: 0.73-0.98, P = 0.02; I 2 = 56%). Conclusion: The use of OAC before visit had no beneficial effect on all-cause mortality in COVID-19 patients. © 2023 Tzu Chi Medical Journal.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: antivitamin K; apixaban; dabigatran; edoxaban; enoxaparin; rivaroxaban; warfarin; adult; aged; all cause mortality; anticoagulation; Article; coronavirus disease 2019; data base; female; hazard ratio; human; male; Medline; meta analysis; middle aged; mortality; sample size; very elderly
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Ngesti Gandini
Date Deposited: 20 Jun 2024 02:51
Last Modified: 20 Jun 2024 02:51
URI: https://ir.lib.ugm.ac.id/id/eprint/2660

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