Optimization of thiamine chitosan nanoemulsion production using sonication treatment

Tahir, Iqmal and Millevania, Justitia and Wijaya, Karna and Mudasir, Mudasir and Wahab, Roswanira Abdul and Kurniawati, Widi (2023) Optimization of thiamine chitosan nanoemulsion production using sonication treatment. Results in Engineering, 17: 100919. pp. 1-9. ISSN 25901230

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Abstract

The production of thiamine chitosan nanoemulsion via sonication treatment has been optimized using response
surface methodology (RSM). This study examines the effect of sonication treatment on thiamine chitosan
formulation and variations in time, amplitude, and surfactant concentration to distinguish optimum production
conditions. Chitosan thiamine nanoemulsion was prepared using the central composite design (CCD) with 3
independent variables (time, amplitude, and surfactant concentration), which generated 20 experimental points.
The optimum condition was determined by analyzing the response variable, which, in this study, is viscosity. The
analysis was carried out using the Minitab 18 software. The sample as formulated using the optimum conditions
derived were then tested for particle size using a Particle Size Analyzer (PSA). The results showed that the 3-
factorial design and response surface methodology could determine the optimum conditions for the formulation
process of chitosan thiamine nanoemulsion. The optimum viscosity of the thiamine chitosan nanoemulsion
determined was 10.5 mPa s which was obtained with 55.2 min sonication time, Tween 80 surfactant concentration
of 3.4%, and amplitude of 56.8 m. The chitosan thiamine nanoemulsion produced with these conditions
had a particle size of 20.1 nm and a polydispersity index of 0.446, which indicated that it was stable and
homogeneous

Item Type: Article
Uncontrolled Keywords: Central composite design; Response surface method; Thiamine chitosan nanoemulsion; Viscosity
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Mathematics and Natural Sciences > Chemistry Department
Depositing User: Masrumi Fathurrohmah
Date Deposited: 21 Aug 2024 07:10
Last Modified: 21 Aug 2024 07:10
URI: https://ir.lib.ugm.ac.id/id/eprint/2729

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