Colonic Myenteric Plexus Neurodegeneration and Minor Colon Inflammation in Trimethyltin-induced Rat Model of Neurodegeneration

Septyaningtrias, Dian Eurike and Zulfa, Hilizza Awalina and Ramadhani, Mahayu Firsty and Sumaryati, Sumaryati and Sulistyawati, Dewi and Paramita, Dewi Kartikawati and Sumiwi, Yustina Andwi Ari and Susilowati, Rina (2023) Colonic Myenteric Plexus Neurodegeneration and Minor Colon Inflammation in Trimethyltin-induced Rat Model of Neurodegeneration. Journal of Histochemistry and Cytochemistry, 71 (6). 333 - 344. ISSN 00221554

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Abstract

Gastrointestinal symptoms are common health problems found during aging and neurodegenerative diseases. Trimethyltin-induced rat is known as an animal model of hippocampal degeneration with no data on enteric neurodegeneration. This study aimed to investigate the effect of trimethyltin (TMT) induction on the gastrointestinal tract. A 28-day animal study with male Sprague–Dawley rats (3 months old, 150–200 g) given a single TMT injection (8 mg/kg body weight, intraperitoneal) was conducted. The number of neurons in the colonic myenteric plexus was measured using stereological estimation. Histological scoring of colon inflammation, immunohistochemistry of tumor necrosis factor-α (TNF-α), and quantitative PCR were conducted. This study showed neuronal loss in the colonic myenteric plexus of TMT-induced rat model of neurodegeneration. Minor colon inflammation characterized by inflammatory cell infiltration and slightly higher expression of TNF-α in the colon mucosa were observed in the TMT-induced rat. However, the gut microbiota composition of the TMT-induced rat was not different from that of the control rats. This study demonstrates that TMT induces colonic myenteric plexus neurodegeneration and minor colon inflammation, which suggests the potential of this animal model to elucidate the communication between the gastrointestinal tract and central nervous system in neurodegenerative diseases.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: enteric nervous system, inflammation, myenteric plexus, neurodegeneration, rat colon, TNF-α, trimethyltin
Subjects: R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Maniso Maniso
Date Deposited: 22 Aug 2024 01:43
Last Modified: 22 Aug 2024 01:59
URI: https://ir.lib.ugm.ac.id/id/eprint/2770

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