Relationship between Phenotype Models Based on Waist Circumference and Triglyceride Levels and the Risk of Chronic Kidney Disease: A Systematic Review and Meta-analysis

Japar, Karunia Valeriani and Hariyanto, Timotius Ivan and Mardjopranoto, Mochammad Sjabani (2023) Relationship between Phenotype Models Based on Waist Circumference and Triglyceride Levels and the Risk of Chronic Kidney Disease: A Systematic Review and Meta-analysis. Journal of Obesity and Metabolic Syndrome, 32 (3). pp. 236-246. ISSN 25086235

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Abstract

Background: Chronic kidney disease (CKD) is a leading cause of death worldwide and has a high cost of treatment. Studies have indicated that a combination of waist circumference (WC) and triglyceride (TG) levels can be used to determine the risk of CKD. This study analyzes the risk of CKD using four phenotype models based on WC and TG. Methods: This meta-analysis analyzes 113,019 participants from 13 studies. We conducted relevant literature searches in the Europe PMC, Medline, and Scopus databases using specific keywords. The results obtained were pooled into odds ratios (ORs) with 95 confidence intervals (CIs) using random-effects models. Results: Our pooled analysis revealed that the highest significant independent association was between CKD and the high WC-high TG phenotype (adjusted OR, 1.61; 95 CI, 1.39 to 1.88; P<0.00001; I2= 59), followed by the high WC-normal TG phenotype (adjusted OR, 1.33; 95 CI, 1.12 to 1.57; P= 0.001; I2= 67), and the normal WC-high TG phenotype (adjusted OR, 1.20; 95 CI, 1.06 to 1.37; P= 0.005; I2= 29) when the normal WC-normal TG phenotype was taken as the reference. Conclusion: Our study suggests that phenotype models based on WC and TG can be used as screening tools to predict the risk of CKD. Our results also indicate that WC plays a larger role than TG in the CKD risk. Further prospective studies are needed to confirm the results of our study.

Item Type: Article
Additional Information: Library Dosen
Uncontrolled Keywords: triacylglycerol; adult; aged; Article; chronic kidney failure; disease association; female; human; male; meta analysis; phenotype; risk; systematic review; triacylglycerol level; waist circumference
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Ngesti Gandini
Date Deposited: 05 Jul 2024 03:14
Last Modified: 05 Jul 2024 03:14
URI: https://ir.lib.ugm.ac.id/id/eprint/2776

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