Edyanto, Abdullah Syafiq and Huriyati, Emy and Nisa, Ainun and Nurrahma, Bira Arumndari and Farmawati, Arta (2023) Iron-fortified klutuk banana (Musa balbisiana Colla) flour supplementation prevented growth failure by suppressing FGF21 in malnourished rats. Nutrition and Food Science, 53 (7). 1166 -1178. ISSN 00346659
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Abstract
Purpose: Malnutrition during childhood precedes growth failure and affects the child’s well-being later in life. This study aims to investigate the potency of iron-fortified klutuk banana (Musa balbisiana Colla) flour on growth parameters and fibroblast growth factor 21 (FGF21) expression in malnourished rat model. Design/methodology/approach: Rats were allocated into normal control (NC), untreated malnutrition (MC), malnutrition + iron-fortified klutuk banana flour (IBF) and malnutrition + Indonesian Government-issued biscuit (GB). Malnutrition was induced by an isoenergetic low-protein diet for five weeks. The IBF and GB groups were supplemented with IBF 1.2 g/200 gBW and GB 1.2 g/200 gBW, respectively, via gavage daily for three weeks. The body weight and length, the levels of plasma and liver FGF21 and red blood cell indices were analyzed. Findings: After three weeks of supplementation, the IBF group showed higher body weight (245 ± 13.6 g vs 201.8 ± 16.3 g; p = 0.0004) and length (20.9 ± 0.5 cm vs 19.8 ± 0.5 cm; p = 0.021) compared with the untreated group. The plasma FGF21 level decreased in the IBF group (p = 0.034). The IBF group altered mean corpuscular volume and mean corpuscular hemoglobin, suggesting the IBF might attenuate malnutrition-induced anemia. Overall, the IBF prevented growth failure in malnourished condition. This might be mediated by the suppression of FGF21 expression, along with the prevention of malnutrition and anemia. Originality/value: This study provides preliminary information about the potential use of rarely consumed banana, klutuk banana, as a supplement to treat malnutrition. This study might help the developing countries to eliminate the widespread malnutrition in economically challenged communities. © 2023, Emerald Publishing Limited.
Item Type: | Article |
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Additional Information: | Cited by: 0 |
Uncontrolled Keywords: | Malnutrition; Musa balbisiana Colla; Iron; FGF21; Growth failure |
Subjects: | R Medicine > RZ Other systems of medicine |
Divisions: | Faculty of Medicine, Public Health and Nursing > Nursing |
Depositing User: | Ani PURWANDARI |
Date Deposited: | 22 Aug 2024 08:30 |
Last Modified: | 22 Aug 2024 08:30 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/2887 |