Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine Alzheimer’s like mediated by inhibition of neuronal apoptotic

Wihadmadyatami, Hevi and Zulfikar, Muhammad Ali and Herawati, Herawati and Pratama, Dyah Ayu and Saragih, Golda Rani and Kustiati, Ulayatul and Handayani, Nurrahmi (2023) Chitosan hydrogel nanoparticle enhance therapeutic effect of bovine umbilical mesenchymal stem cell conditioned medium on canine cognitive dysfunction or canine Alzheimer’s like mediated by inhibition of neuronal apoptotic. Open Veterinary Journal, 13 (12). pp. 1504-1516. ISSN 2226-4485

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Abstract

In treating brain diseases, such as canine cognitive dysfunction (CCD), most currently available potent drugs have weak therapeutic efficacy. One of the causes is the inability of the substance to reach the brain in therapeutic quantities. These pharmaceuticals lacked targeted mechanisms for drug delivery, coming about in an elevated drug concentration in imperative organs, which drove to drug harmfulness. In recent years, cell-free treatment (conditioned medium) determined from animal and human stem cells has provided new promise for treating brain diseases, as CM can stimulate the regeneration of neurons and prevent the inflammation and apoptotic of neurons caused by pathology or aging. On the other hand, it is well known that chitosan-hydrogel (CH) is a polymer derived from natural sources. It has been authorized for use in biomedical use because of its uncommon biodegradability, biocompatibility, and mucoadhesive properties. CH modification has been utilized to generate nanoparticles (NPs) for intranasal and intravenous brain targeting. NPs shown upgraded drug take-up to the brain with decreased side impacts due to their drawn out contact time with the nasal mucosa, surface charge, nanosize, and capacity to extend the tight intersections inside the mucosa. Due to the aforementioned distinctive characteristics, developing Chitosan Hydrogel Nanoparticles load with bovine umbilical mesenchymal stem cell conditioned medium is crucial as a new therapeutic strategy for CCD

Item Type: Article
Uncontrolled Keywords: Bovine umbilical mesenchymal stem cell, Canine cognitive dysfunction, Cell-free therapy, Chitosan hydrogel nanoparticle, Secretome.
Subjects: S Agriculture > SF Animal culture
Divisions: Faculty of Veterinary Medicine
Depositing User: Erlita Cahyaningtyas Cahyaningtyas
Date Deposited: 17 Sep 2024 04:39
Last Modified: 17 Sep 2024 04:39
URI: https://ir.lib.ugm.ac.id/id/eprint/3288

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