A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems

Nugrahaningsih, Dwi Aris and Wihadmadyatami, Hevi and Widyarini, Sitarina and Wijayaningsih, Rahmi Ayu (2023) A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems. International Journal of Genomics, 2023. pp. 1-13. ISSN 2314436X

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Abstract

Air pollution is one of the significant environmental risks known as the cause of premature deaths. It has deleterious effects on human health, including deteriorating respiratory, cardiovascular, nervous, and endocrine functions. Exposure to air pollution stimulates
reactive oxygen species (ROS) production in the body, which can further cause oxidative stress. Antioxidant enzymes, such as glutathione S-transferase mu 1 (GSTM1), are essential to prevent oxidative stress development by neutralizing excess oxidants. When the antioxidant enzyme function is lacking, ROS can accumulate and, thus, cause oxidative stress. Genetic variation studies from different countries show that GSTM1 null genotype dominates the GSTM1 genotype in the population. However, the impact of the GSTM1 null genotype in modifying the association between air pollution and health problem is not yet clear. This study will elaborate on GSTM1’s null genotype role in modifying the relationship between air pollution and health problems.

Item Type: Article
Subjects: S Agriculture > SF Animal culture
Divisions: Faculty of Veterinary Medicine
Depositing User: Erlita Cahyaningtyas Cahyaningtyas
Date Deposited: 12 Sep 2024 04:14
Last Modified: 12 Sep 2024 04:14
URI: https://ir.lib.ugm.ac.id/id/eprint/3563

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