Factors associated with mortality in intracranial infection patients admitted to pediatric intensive care unit: A retrospective cohort study

Kholifia, Asmaul and Rusmawatiningtyas, Desy and Makrufardi, Firdian and Laksanawati, Ida Safitri and Kumara, Intan Fatah and Nurnaningsih, Nurnaningsih (2021) Factors associated with mortality in intracranial infection patients admitted to pediatric intensive care unit: A retrospective cohort study. Annals of Medicine and Surgery, 70. ISSN 20490801

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Abstract

Background: Intracranial infection is a major cause of emergency and death in children. To assist clinical decision-making in patient management, we conducted a study about factors associated with mortality. This study aimed to evaluate factors associated with mortality in pediatric patients with intracranial infection. Methods: We performed a cohort retrospective study in our tertiary hospital to evaluate the outcomes of patients admitted to the pediatric intensive care unit (PICU) from 2014 to 2018. The Chi-square test was performed to determine the significance of the predictor, and p < 0.05 was considered to indicate a statistically significant result. We used multivariate logistic regression to determine relative risk (RR) with 95 confidence interval (CI). Results: We recruited 112 patients who were admitted to the PICU of our tertiary hospital. A total of 38.4 were diagnosed with encephalitis, 9.8 meningitis and 51.8 meningoencephalitis. Of the 112 patients who met the inclusion criteria, 28 (25) patients died in the PICU. The need of mechanical ventilation support variable had a statistically significant association with mortality (RR 22.76; 95 CI: 3.88–51.45). Conclusion: Recognition of conditions that exacerbate intracranial infection in children needs to be done as early as possible. Moreover, the need of mechanical ventilation support in the PICU needs more attention. © 2021

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access
Uncontrolled Keywords: Acinetobacter baumannii; adolescent; alpha hemolytic Streptococcus; anemia; Article; artificial ventilation; bacterium culture; brain edema; Burkholderia cepacia; cerebrospinal fluid analysis; child; coagulase negative Staphylococcus; cohort analysis; computer assisted tomography; controlled study; Cronobacter sakazakii; encephalitis; Enterobacter cloacae; epileptic state; female; Glasgow coma scale; hospitalization; human; hyponatremia; incidence; infant; Klebsiella pneumoniae; Kocuria kristinae; Kocuria rosea; length of stay; major clinical study; male; meningitis; meningoencephalitis; Micrococcus luteus; mortality rate; outcome assessment; patient care; pediatric intensive care unit; pediatric patient; Pseudomonas aeruginosa; retrospective study; risk factor; Staphylococcus epidermidis; Staphylococcus haemolyticus; Staphylococcus hominis; Staphylococcus warneri
Subjects: R Medicine > RD Surgical Divisions
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 26 Sep 2024 08:22
Last Modified: 26 Sep 2024 08:22
URI: https://ir.lib.ugm.ac.id/id/eprint/4598

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