Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival

Hartanto, Rachmat Andi and Dwianingsih, Ery Kus and Panggabean, Andre Stefanus and Wicaksono, Adiguno Suryo and Dananjoyo, Kusumo and Asmedi, Ahmad and Malueka, Rusdy Ghazali (2021) Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival. Asian Pacific Journal of Cancer Prevention, 22 (3). 691 – 697. ISSN 15137368

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Abstract

Objective: Seizure is commonly found in patients with glioma. This study aimed to find risk factors for seizures in Indonesian patients with glioma. We also sought to determine the association between seizure and survival in this patient population. Methods: Patients with glioma were enrolled from the Dr. Sardjito General Hospital and other hospitals in Yogyakarta Province, Indonesia. Detailed demographic and clinical data were collected from medical records. DNA extraction and polymerase chain reaction (PCR) were performed to detect IDH1 mutation. Tumor tissue samples were stained by hematoxylin-eosin and classified according to the 2016 World Health Organization (WHO) classification of central nervous system (CNS) tumors. Expression of Ki-67 was detected by immunohistochemistry staining. Survival data were also collected. Results: In total, 107 patients were included in the analysis. Age, gender, history of smoking, tumor side, tumor grade, Ki-67 expression, and IDH1 mutation were not associated with seizure. Tumors involving the frontal lobe (p=0.037) and oligodendroglioma histology (p=0.031) were associated with the development of seizures in this study. However, multivariate analysis showed that only oligodendrogial histology was associated with seizure p=0.032, odds ratio (OR) = 4.77, 95% confidence interval (CI) = 1.146-19.822. Patients with seizures have significantly longer median overall survival than patients without seizures (69.3±25.01 vs. 10.6±6.14 months, respectively, p=0.04). Conclusion: This study showed that seizure in patients with glioma in Indonesia is associated with frontal lobe location and oligodendroglioma histology. Patients with seizures also have significantly longer overall survival. © 2021. All Rights Reserved.

Item Type: Article
Additional Information: Cited by: 4; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Adult; Brain Neoplasms; Female; Frontal Lobe; Glioma; Humans; Indonesia; Male; Middle Aged; Odds Ratio; Oligodendroglioma; Prognosis; Risk Factors; Seizures; Survival Rate; Young Adult; adult; brain tumor; complication; female; frontal lobe; glioma; human; Indonesia; male; middle aged; odds ratio; oligodendroglioma; pathology; prognosis; risk factor; seizure; survival rate; young adult
Subjects: R Medicine > RD Surgical Divisions
Divisions: Faculty of Medicine, Public Health and Nursing > Public Health and Nutrition
Depositing User: Sri JUNANDI
Date Deposited: 17 Sep 2024 05:47
Last Modified: 17 Sep 2024 05:47
URI: https://ir.lib.ugm.ac.id/id/eprint/4862

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