Genetic variation of a −176g>c interleukin-6 correlated with white blood cells count in obesity of indonesia

Danarsih, Dwi Eni and Hastuti, Pramudji and Kristianto, Agus (2021) Genetic variation of a −176g>c interleukin-6 correlated with white blood cells count in obesity of indonesia. Open Access Macedonian Journal of Medical Sciences, 9. 324 – 327. ISSN 18579655

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Abstract

BACKGROUND: Obesity is a risk factor for cardiovascular disease. Obesity can trigger inflammation by increasing the synthesis of interleukin-6 (IL-6) which leads to leukocyte recruitment, differentiation of B lymphocytes, activating T lymphocyte cells, and triggering hematopoiesis. Variations in the IL-6 promoter gene are known to affect transcription rates. The previous studies have still found different results regarding the relationship between these gene variations and blood cell numbers. AIM: This study aimed to determine the influence of IL-6 gene variation with white blood cells counts in obese people of Indonesia. METHODS: A total of 148 people participated in this cross-sectional study. The number of obese people was 80 subjects and there were 68 non-obese people as controls. Obesity was determined based on the criteria of Asians. RESULTS: Genotype CC was not found in this study, while the GC genotype was found only in the obese group. The GG genotype in obese group had waist circumference, diastolic blood pressure, and higher lymphocyte rates significantly higher than the non-obese group (p < 0.05). CONCLUSIONS: Variation of −174G>C IL-6 gene is associated with high white blood cell counts, especially lymphocytes number in obese people in Indonesia. © 2021 Dwi Eni Danarsih, Pramudji Hastuti, Agus Kristianto.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access
Uncontrolled Keywords: interleukin 6; adult; anthropometry; Article; body mass; controlled study; cross-sectional study; diastolic blood pressure; DNA isolation; female; genetic variation; genotype; hematological parameters; human; Indonesia; leukocyte count; male; obesity; polymerase chain reaction restriction fragment length polymorphism; systolic blood pressure; waist circumference
Subjects: R Medicine > RP Public Health and Nutrition
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Sri JUNANDI
Date Deposited: 13 Sep 2024 07:55
Last Modified: 13 Sep 2024 07:55
URI: https://ir.lib.ugm.ac.id/id/eprint/4884

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