Expanded principles of ethics and its implementation during COVID-19 vaccine trials: A scoping evidence based research synthesis

Kumar, Vaibhav and Aranha, Venetia and Rajgarhia, Rajni and Royal, Abhishek and Mehta, Kedar (2021) Expanded principles of ethics and its implementation during COVID-19 vaccine trials: A scoping evidence based research synthesis. Human Vaccines and Immunotherapeutics, 17 (11). 3843 – 3849. ISSN 21645515

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Abstract

The COVID-19 pandemic will subside only through the emergence and distribution of an efficacious vaccine. The two main aspects that should be maintained in equilibrium: the dire necessity for speedy vaccine research and the need for safeguarding the research subjects, which is of utmost concern in research ethics. This opens up a discussion of what norms to follow during the clinical trials while developing the vaccine. As of now, various companies like Moderna, Pfizer, University of Oxford, Astra-Zeneca and so on have moved beyond the safety, efficacy and immunogenic studies. This narrative review explores and discusses the key principles of ethics: a principle of autonomy, beneficence, non-maleficence, and justice along with its ten general expanded principles. Furthermore, it delves into the different types of vaccines, their mechanisms, side effects, limitations, and advantages. © 2021 Taylor & Francis Group, LLC.

Item Type: Article
Additional Information: Cited by: 2; All Open Access, Hybrid Gold Open Access
Uncontrolled Keywords: COVID-19; COVID-19 Vaccines; Humans; Pandemics; SARS-CoV-2; DNA vaccine; SARS-CoV-2 vaccine; allergy; anxiety; Article; autoimmune disease; beneficence; coronavirus disease 2019; decision making; diabetes mellitus; disease transmission; drug efficacy; drug safety; human; hypertension; inflammation; injection site reaction; justice; myocarditis; negligence; nonmaleficence; nose smear; pandemic; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phlebotomy; research subject; respiratory syncytial virus infection; risk assessment; screening test; social distancing; synthesis; thrombocytopenia; vaccination
Subjects: R Medicine > RP Public Health and Nutrition
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Sri JUNANDI
Date Deposited: 13 Sep 2024 04:14
Last Modified: 13 Sep 2024 04:14
URI: https://ir.lib.ugm.ac.id/id/eprint/4903

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