Association between anterior chamber angle and corneal endothelial cell density in chronic angle closure

Soebijantoro, Iwan and Gondhowiardjo, Tjahjono D. and Soesatyo, Marsetyawan (2021) Association between anterior chamber angle and corneal endothelial cell density in chronic angle closure. Clinical Ophthalmology, 15. 1957 – 1964. ISSN 11775467

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Abstract

Purpose: To study the association between corneal endothelial cell density (ECD) and degree of anterior chamber angle (ACA) opening in eyes with chronic angle closure glaucoma. Methods: The study was conducted at JEC Eye Hospitals in Indonesia. Treatment-naïve patients aged ≥40 years with IOP >21 mmHg and peripheral anterior chamber depth (ACD) grade 2 or less by Van Herick’s technique were recruited. Trabecular iris angle (TIA; degree) was measured using anterior segment optical coherence tomography (AS-OCT) and classi-fied as: grade 1 ≤10°, grade 2 11–20°, and grade 3 >20°. Noncontact specular microscopy was performed, and the following corneal parameters were obtained:ECD (cells/mm2), coefficient of variation (CV; μm2/cell), percentage of hexagonal cells, and central corneal thickness (CCT; μm). Results: A total of 52 eyes from 52 subjects were recruited (16 grade 1 TIA, 24 grade 2 TIA, and 12 grade 3 TIA). Presenting IOP was not significantly different between groups. The median central corneal ECD was 2684.5 (1433–2934), 2587.0 (1902–3103), and 2441.0 (1659–3005) cells/mm2 in grade 1, 2, and 3 TIA, respectively, with no significant differences across the groups (P = 0.67). The CV was lowest in grade 3 TIA (36.4 ± 7.2 μm2/cell), and highest in grade 1 TIA (38.3 ± 9.6 μm2/cell), but the differences were not significant (P = 0.74). Likewise, the percentage of hexagonality and CCT was not significantly different. TIA was not correlated with IOP but was modestly correlated with age. Conclusion: The corneal ECD and morphological characteristics such as CV and hexagonality were not significantly different across various TIA grading in chronic angle closure. This may reflect the lack of chronic and gradual IOP insult on corneal endothelial parameters as TIA did not show direct effect towards IOP. © 2021 Soebijantoro et al.

Item Type: Article
Additional Information: Cited by: 0; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: adult; age distribution; aged; anterior eye chamber angle; anterior eye chamber depth; anterior eye segment; Article; cell density; central corneal thickness; closed angle glaucoma; controlled study; cornea endothelium; correlation coefficient; cross-sectional study; disease classification; female; human; human cell; Indonesia; intraocular pressure; major clinical study; male; optical coherence tomography; population research; specular microscopy; trabecular iris angle; visual system parameters
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Public Health and Nursing > Biomedical Sciences
Depositing User: Sri JUNANDI
Date Deposited: 29 Aug 2024 07:44
Last Modified: 29 Aug 2024 07:44
URI: https://ir.lib.ugm.ac.id/id/eprint/4917

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