Deng, Lin and Solichin, Muchamad Ridotu and Adyaksa, Dewa Nyoman Murti and Septianastiti, Maria Alethea and Fitri, Rhamadianti Aulia and Suwardan, Gede Ngurah Rsi and Matsui, Chieko and Abe, Takayuki and Shoji, Ikuo (2023) Cellular Release of Infectious Hepatitis C Virus Particles via Endosomal Pathways. Viruses, 15 (12): 2430. pp. 1-12. ISSN 19994915
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Abstract
Hepatitis C virus (HCV) is a positive-sense, single-stranded RNA virus that causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The release of infectious HCV particles from infected hepatocytes is a crucial step in viral dissemination and disease progression. While the exact mechanisms of HCV particle release remain poorly understood, emerging evidence suggests that HCV utilizes intracellular membrane trafficking and secretory pathways. These pathways include the Golgi secretory pathway and the endosomal trafficking pathways, such as the recycling endosome pathway and the endosomal sorting complex required for transport (ESCRT)-dependent multivesicular bodies (MVBs) pathway. This review provides an overview of recent advances in understanding the release of infectious HCV particles, with a particular focus on the involvement of the host cell factors that participate in HCV particle release. By summarizing the current knowledge in this area, this review aims to contribute to a better understanding of endosomal pathways involved in the extracellular release of HCV particles and the development of novel antiviral strategies. © 2023 by the authors.
Item Type: | Article |
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Additional Information: | Library Dosen |
Uncontrolled Keywords: | coat protein complex II; Rab protein; ESCRT protein, antiviral activity; biogenesis; cell membrane; cell migration; endosomal pathway; endosomal sorting complex required for transport machinery; endosome; exocytosis; Golgi complex; golgi secretory pathway; hepatitis C; Hepatitis C virus; host cell; JNK signaling; multivesicular body; nonhuman; recycling; Review; secretory pathway; signal transduction; trans Golgi network; upregulation; virus particle; virus release; Hepacivirus; hepatitis A; hepatitis C; human; metabolism; virion; virus release, Endosomal Sorting Complexes Required for Transport; Endosomes; Hepacivirus; Hepatitis A; Hepatitis C; Humans; Virion; Virus Release |
Subjects: | R Medicine > RC Internal medicine |
Divisions: | Faculty of Medicine, Public Health and Nursing > Biomedical Sciences |
Depositing User: | Ani PURWANDARI |
Date Deposited: | 12 Jun 2024 08:37 |
Last Modified: | 21 Aug 2024 03:53 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/556 |