Animal Models of Alcoholic Liver Disease for Hepatoprotective Activity Evaluation

Renggani, Hidayah Dwi and Hertianti, Triana and Murwanti, Retno (2021) Animal Models of Alcoholic Liver Disease for Hepatoprotective Activity Evaluation. In: BIO Web of Conferences 41, 07007 (2021).

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Abstract

Background: The reported statistics suggest that alcoholic liver disease is on the rise. Furthermore, medications used to treat the disease have unpleasant effects, and this necessitates the need to continuously investigate hepatoprotective agents. This study investigates animal models of alcoholic liver disease used to evaluate hepatoprotective activity. Content: A good number of published articles evaluating hepatoprotective activity were summarized. The studies used three ethanol-induced liver injury models: the acute ethanol-induced liver injury model, the chronic ethanol-induced liver injury model, and Lieber-DeCarli model. Summary: Wistar rats were primarily used in the ethanol-induced liver injury model. High levels of alanine transaminase (ALT) and aspartate transaminase (AST) and histopathological alterations were found in all animal models (acute ethanol-induced liver injury, chronic ethanol-induced liver injury, and Lieber-DeCarli models). Severe steatosis was shown in both chronic ethanol-induced liver injury and Lieber-DeCarli models. However, fibrosis was undetected in all models. © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/).

Item Type: Conference or Workshop Item (Paper)
Additional Information: Cited by: 0; Conference name: 4th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering, BioMIC 2021; Conference date: 6 October 2021 through 7 October 2021; Conference code: 192780; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: Alcoholic liver disease; animal models; hepatoprotective activity; liver injury; ethanol
Subjects: Veterinary Medicine
Divisions: Faculty of Veterinary Medicine
Depositing User: Sri JUNANDI
Date Deposited: 25 Oct 2024 06:03
Last Modified: 25 Oct 2024 06:03
URI: https://ir.lib.ugm.ac.id/id/eprint/5597

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