Anthelmintic and antimicrobial activities of three new depsides and ten known depsides and phenols from Indonesian lichen: Parmelia cetrata Ach.

Nugraha, Ari Satia and Untari, Ludmilla Fitri and Laub, Annegret and Porzel, Andrea and Franke, Katrin and Wessjohann, Ludger A. (2021) Anthelmintic and antimicrobial activities of three new depsides and ten known depsides and phenols from Indonesian lichen: Parmelia cetrata Ach. Natural Product Research, 35 (23). 5001 – 5010. ISSN 14786419

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Abstract

An extensive phytochemical study of a foliose lichen from Indonesia, Parmelia cetrata, resulted in the successful isolation of 13 phenol and depside derivatives (1–13) including the previously unreported depsides 3′-hydroxyl-5′-pentylphenyl 2,4-dihydroxyl-6-methylbenzoate (7), 3′-hydroxyl-5′-propylphenyl 2,4-dihydroxyl-6-methylbenzoate (8) and 3′-hydroxyl-5′-methylphenyl 2-hydroxyl-4-methoxyl-6-propylbenzoate (9). The anti-infective activity of isolated compounds was evaluated against the gram-negative bacterium Aliivibrio fischeri and the nematode Caenorhabditis elegans. 2,4-Dihydroxyl-6-pentylbenzoate (5) and lecanoric acid (6) induced growth inhibition of A. fischeri with inhibition values of 49 and 100 at a concentration of 100 µM, respectively. The antibacterial activity might be due to their free carboxyl group. A phenolic group at C4 also contributed to the antimicrobial activity of the depsides as shown for compounds 7 and 8, which caused 89 and 96 growth inhibition at 100 µM, respectively. Lecanoric acid (6) in addition possesses significant anthelmintic effects causing 80 mortality of C. elegans at 100 µg/mL. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited by: 12
Uncontrolled Keywords: Animals; Anthelmintics; Anti-Infective Agents; Caenorhabditis elegans; Depsides; Indonesia; Lichens; Phenols; 2,4 dihydroxy 6 pentylbenzoate; 3' hydroxy 5' pentylphenyl 2 hydroxy 4 methoxy 6 propylbenzoate; 3' hydroxy 5' propylphenyl 2 hydroxy 4 methoxy 6 pentylbenzoate; 3' hydroxy 5' propylphenyl 2 hydroxy 4 methoxy 6 propylbenzoate; 3' hydroxyl 5' methylphenyl 2 hydroxyl 4 methoxyl 6 propylbenzoate; 3' hydroxyl 5' pentylphenyl 2,4 dihydroxyl 6 methylbenzoate; 3' hydroxyl 5' propylphenyl 2,4 dihydroxyl 6 methylbenzoate; 3' methoxy 5' propylphenyl 2 hydroxy 4 methoxy 6 propylbenzoate; 5 propylresorcinol; chloramphenicol; depside; ivermectin; lecanoric acid; methyl 2 hydroxy 4,6 dimethylbenzoate; methyl 2,4 dihydroxy 6 methylbenzoate; orcinol; phenol derivative; unclassified drug; anthelmintic agent; antiinfective agent; depside; phenol derivative; Aliivibrio fischeri; anthelmintic activity; antimicrobial activity; Article; Caenorhabditis elegans; controlled study; drug isolation; drug structure; growth inhibition; Indonesia; lichen (organism); nonhuman; Parmelia cetrata; animal; lichen (organism)
Subjects: Biology
Divisions: Faculty of Biology > Doctoral Program in Biology
Depositing User: Sri JUNANDI
Date Deposited: 30 Oct 2024 06:55
Last Modified: 30 Oct 2024 06:55
URI: https://ir.lib.ugm.ac.id/id/eprint/5960

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