A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems

Nugrahaningsih, Dwi Aris Agung and Wihadmadyatami, Hevi and Widyarini, Sitarina and Wijayaningsih, Rahmi Ayu (2023) A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems. International Journal of Genomics, 2023. ISSN 2314436X

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Abstract

Air pollution is one of the significant environmental risks known as the cause of premature deaths. It has deleterious effects on human health, including deteriorating respiratory, cardiovascular, nervous, and endocrine functions. Exposure to air pollution stimulates reactive oxygen species (ROS) production in the body, which can further cause oxidative stress. Antioxidant enzymes, such as glutathione S-transferase mu 1 (GSTM1), are essential to prevent oxidative stress development by neutralizing excess oxidants. When the antioxidant enzyme function is lacking, ROS can accumulate and, thus, cause oxidative stress. Genetic variation studies from different countries show that GSTM1 null genotype dominates the GSTM1 genotype in the population. However, the impact of the GSTM1 null genotype in modifying the association between air pollution and health problem is not yet clear. This study will elaborate on GSTM1's null genotype role in modifying the relationship between air pollution and health problems. © 2023 Dwi Aris Agung Nugrahaningsih et al.

Item Type: Article
Additional Information: Cited by: 2; All Open Access, Gold Open Access, Green Open Access
Uncontrolled Keywords: glutathione transferase M1; air pollutant; air pollution; antioxidant activity; cardiovascular disease; endocrine disease; environmental exposure; genetic variation; genotype; health; human; neurologic disease; nonhuman; oxidative stress; particulate matter; respiratory tract disease; Review
Subjects: Veterinary Medicine
Divisions: Faculty of Veterinary Medicine
Depositing User: Sri JUNANDI
Date Deposited: 01 Nov 2024 02:57
Last Modified: 01 Nov 2024 02:57
URI: https://ir.lib.ugm.ac.id/id/eprint/6103

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