Mulyati, Mulyati and Syariatin, Lasmini and Sofyantoro, Fajar (2024) Supplementation of Chlorella vulgaris Ameliorates the Stress-induced Hematological Alterations in Wistar Rats. Pertanika Journal of Tropical Agricultural Science, 47 (1): 10. 131 – 146. ISSN 1511-3701
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Abstract
Stress has been associated with various diseases and physiological disruptions. Chlorella vulgaris is known for its antioxidant properties. This study examined the effects of C. vulgaris on the hematological profile of stress-induced Wistar rats. Stress significantly impacted
various hematological parameters, including erythrocyte count, hemoglobin concentration, hematocrit levels, white blood cell count, and platelet count. The supplementation of
cultivated C. vulgaris effectively restored erythrocyte count and suppressed elevated lymphocyte levels, while commercially available C. vulgaris and amitriptyline drugs had no significant effects on these parameters. Stress caused smaller-sized erythrocytes but did not significantly affect mean corpuscular volume. Both amitriptyline and C. vulgaris restored platelet levels, while mean platelet volume remained unaffected. Overall, C. vulgaris showed promise as a therapeutic intervention for countering stress-induced inhibition of erythropoiesis and restoring erythrocyte count, but more research is needed to understand
the underlying mechanisms and develop effective strategies for managing stress-related changes in hematological parameters.
Item Type: | Article |
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Additional Information: | Cited by: 0 |
Uncontrolled Keywords: | Chlorella vulgaris, hematological profile, rats, stress |
Subjects: | R Medicine > RX Homeopathy |
Divisions: | Faculty of Biology > Undergratuate Program in Biology |
Depositing User: | Ekowati Purwandari Purwandari |
Date Deposited: | 06 Sep 2024 06:14 |
Last Modified: | 06 Sep 2024 06:14 |
URI: | https://ir.lib.ugm.ac.id/id/eprint/6407 |